Evidence map›Paper›PMID 28165774›Full record

ArticleCancer investigation2017

Factors and Costs Associated With Delay in Treatment Initiation and Prolonged Length of Stay With Inpatient EPOCH Chemotherapy in Patients With Hematologic Malignancies.

Melissa K Accordino, Jason D Wright, Sowmya Vasan, Alfred I Neugut, Grace C Hillyer, Dawn L Hershman

Abstract read
In one paragraph

Article in Cancer investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melissa K Accordinoa Department of Medicine College of Physicians and Surgeons , Columbia University , New York , NY , USA.
Jason D Wrightb Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons , Columbia University , New York , NY , USA.
Sowmya Vasand Department of Epidemiology, Mailman School of Public Health , Columbia University , New York , NY , USA.
Alfred I Neuguta Department of Medicine College of Physicians and Surgeons , Columbia University , New York , NY , USA.
Grace C Hillyerb Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons , Columbia University , New York , NY , USA.
Dawn L Hershmana Department of Medicine College of Physicians and Surgeons , Columbia University , New York , NY , USA.

Funding

The Influence of Hospital Variability on the Management of Cancer-Associated CompR01CA169121 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WRIGHT, JASON · 2013 to 2017
$1.8M
Using SWOG-Medicare database to evaluate long-term toxicities of cancer survivorsR01CA166084 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERSHMAN, DAWN · 2013 to 2016
$1.3M
Determinants and risks of use and overuse of expensive oncology drugsR01CA134964 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERSHMAN, DAWN · 2008 to 2011
$1.0M
NCI NIH HHS R01 CA134964NCI NIH HHS R01 CA166084NCI NIH HHS R01 CA169121
6 · The paper itself

Abstract

Reducing delays related to inpatient chemotherapy may reduce healthcare costs. Using a national database, we identified patients with lymphoma/leukemia with ≥1 etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (EPOCH) chemotherapy claim and evaluated chemotherapy initiation delay (ID), >1 day from admission. Standard tests/procedures prior to initiation were evaluated. Among 4453 inpatient cycles, 19.7% had ID, odds ratio 2.28 (95% confidence interval: 1.83-2.85) with cycle 1 compared to cycle 2, and mean costs were higher in patients with ID than without ID (p < .0001). Prior to cycle 1, patients were more likely to undergo routine diagnostic procedures compared to subsequent cycles. Efforts to perform routine procedures prior to admission may reduce hospital length of stay and costs.

Indexed as

AdultAgedAntineoplastic Combined Chemotherapy ProtocolsCyclophosphamideDoxorubicinEtoposideFemaleHealth Care CostsHumansInpatientsLength of StayLeukemiaLymphomaMaleMiddle AgedPrednisoneCyclophosphamideDoxorubicinEtoposidePrednisoneVincristineChemotherapyhealth sciences researchoutcomes research

Identifiers

PMID28165774
PMCPMC5700415

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.