Evidence map›Paper›PMID 28165650›Full record

ReviewJournal of magnetic resonance imaging : JMRI2017

MRI assessment of bone structure and microarchitecture.

Gregory Chang, Sean Boone, Dimitri Martel, Chamith S Rajapakse, Robert S Hallyburton, Mitch Valko, Stephen Honig, Ravinder R Regatte

Open access · greenAbstract readReview
In one paragraph

Review in Journal of magnetic resonance imaging : JMRI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 145 citations in OpenAlex.

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  15. Would Roussouly classification affect the diagnostic efficiency of vertebral bone quality score for assessing osteopenia or osteoporosis in lumbar degenerative disease?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gregory ChangDepartment of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA.
Sean BooneDepartment of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA.
Dimitri MartelDepartment of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA.
Chamith S RajapakseDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robert S HallyburtonDepartment of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA.
Mitch ValkoDepartment of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA.
Stephen HonigOsteoporosis Center, Hospital for Joint Diseases, NYU Langone Medical Center, New York, New York, USA.
Ravinder R RegatteDepartment of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA.
NYU Langone Health · USHospital of the University of Pennsylvania · US

Funding

Imaging Biomarkers of Knee OsteoarthritisR01AR068966 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2016 to 2021
$3.1M
Sodium MRI for Assessment of Early OA.R01AR060238 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2011 to 2015
$2.9M
MRI of Proximal Femur Microarchitecture as a Biomarker of Bone QualityR01AR066008 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHANG, GREGORY · 2014 to 2018
$2.8M
Translation of Hip Microarchitectural Assessment Technology to the Clinic to Diagnose Glucocorticoid-Induced OsteoporosisR01AR070131 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHANG, GREGORY · 2016 to 2020
$2.7M
Assessment of Cartilage Repair with Sodium MRI at 3TR01AR067156 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2015 to 2019
$2.3M
Clinical Assessment of Hip Fracture Biomechanics using MRIR01AR068382 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI RAJAPAKSE, CHAMITH SUDESH · 2015 to 2019
$1.8M
NIAMS NIH HHS R01 AR060238NIAMS NIH HHS R01 AR066008NIAMS NIH HHS R01 AR067156NIAMS NIH HHS R01 AR068382NIAMS NIH HHS R01 AR068966NIAMS NIH HHS R01 AR070131
6 · The paper itself

Abstract

Osteoporosis is a disease of weak bone and increased fracture risk caused by low bone mass and microarchitectural deterioration of bone tissue. The standard-of-care test used to diagnose osteoporosis, dual-energy x-ray absorptiometry (DXA) estimation of areal bone mineral density (BMD), has limitations as a tool to identify patients at risk for fracture and as a tool to monitor therapy response. Magnetic resonance imaging (MRI) assessment of bone structure and microarchitecture has been proposed as another method to assess bone quality and fracture risk in vivo. MRI is advantageous because it is noninvasive, does not require ionizing radiation, and can evaluate both cortical and trabecular bone. In this review article, we summarize and discuss research progress on MRI of bone structure and microarchitecture over the last decade, focusing on in vivo translational studies. Single-center, in vivo studies have provided some evidence for the added value of MRI as a biomarker of fracture risk or treatment response. Larger, prospective, multicenter studies are needed in the future to validate the results of these initial translational studies. LEVEL OF EVIDENCE: 5 Technical Efficacy: Stage 5 J. MAGN. RESON. IMAGING 2017;46:323-337.

Indexed as

Magnetic Resonance ImagingAbsorptiometry, PhotonAdultAgedAged, 80 and overBone and BonesBone DensityDiabetes ComplicationsFemaleFinite Element AnalysisFractures, BoneHumansHypogonadismImage Processing, Computer-AssistedMaleMiddle Agedbone mineral density (BMD)bone qualitydual-energy x-ray absorptiometry (DXA)finite element analysis (FEA)fragility fracturesosteoporosis

Identifiers

PMID28165650
PMCPMC5690546
OpenAlexW2586570460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.