ArticleJournal of the American Geriatrics Society2017
Relationship Between Midlife Cardiovascular Health and Late-Life Physical Performance: The ARIC Study.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Effects of hearing intervention on physical function: A secondary analysis of the ACHIEVE study.PloS one · 2026Trial
- Trial
- Physical Performance Changes Across Race and Region Among Black and White Older Adults.JAMA network open · 2026Article
- Sex differences in the association of vascular risk and APOE Genotype with cognitive decline and dementia: evidence from a U.S. longitudinal study.Lancet regional health. Americas · 2026Article
- Prevalence of Peripheral Neuropathy Among Very Old Adults: Evidence From the Michigan Neuropathy Screening Instrument.Journal of the American Geriatrics Society · 2025Article
- Alzheimer's disease plasma biomarkers and physical functioning in a diverse sample of adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Associations Between Prior Head Injury, Physical Functioning, and Frailty in the Atherosclerosis Risk in Communities Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Mid-Life Vascular Risk and Rate of Physical Function Decline Among Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Milk intake across adulthood and muscle strength decline from mid- to late life: the MRC National Survey of Health and Development.The British journal of nutrition · 2023Article
- Clinically Recognized Varicose Veins and Physical Function in Older Individuals: The ARIC Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Gait Characteristics and Cognitive Function in Middle-Aged Adults with and without Type 2 Diabetes Mellitus: Data from ENBIND.Sensors (Basel, Switzerland) · 2022Article
- Midlife Cardiovascular Health and Robust Versus Frail Late-Life Status: The Atherosclerosis Risk in Communities Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study.Brain imaging and behavior · 2021Article
- American Diabetes Association Framework for Glycemic Control in Older Adults: Implications for Risk of Hospitalization and Mortality.Diabetes care · 2021Article
- Association of Age-Related Hearing Impairment With Physical Functioning Among Community-Dwelling Older Adults in the US.JAMA network open · 2021Article
- Contribution of common chronic conditions to midlife physical function decline: The Study of Women's Health Across the Nation.Women's midlife health · 2020Article
- Are Health Behaviors and Self-Rated Health Related to Cardiovascular Health and Functional Performance? Results from the Lookup 7+ Cross-Sectional Survey among Persons Aged 65+.The journal of nutrition, health & aging · 2020Article
- Association of Undifferentiated Dyspnea in Late Life With Cardiovascular and Noncardiovascular Dysfunction: A Cross-sectional Analysis From the ARIC Study.JAMA network open · 2019Article
- Systemic Inflammation and Cardio-Renal Organ Damage Biomarkers in Middle Age Are Associated With Physical Capability Up to 9 Years Later.Circulation · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesTo examine the association between midlife cardiovascular health and physical performance 25 years later.
designCohort study (Atherosclerosis Risk in Communities Study); multinomial logistic and logistic regression adjusted for demographic characteristics and clinical measures.
settingFour U.S. communities: Forsyth County, North Carolina; Washington County, Maryland; Minneapolis, Minnesota; and Jackson, Mississippi.
participantsIndividuals aged 54.2 ± 5.8 at baseline (N = 15,744; 55% female, 27% black). MEASUREMENTS: Cardiovascular health was measured at baseline using the American Heart Association's Life's Simple 7 (LS7) score (0-14) and LS7 component categories (poor, intermediate, ideal) for each risk factor. The Short Physical Performance Battery (SPPB) was used to quantify physical function as ordinal (0-12) and categorical (low (0-6), fair (7-9), good (10-12) outcomes.
resultsMean baseline LS7 score was 7.9 ± 2.4; 6,144 (39%) individuals returned 25 years later for the fifth ARIC examination, at which point the SPPB was administered. Of 5,916 individuals who completed the SPPB, 3,288 (50%) had good physical performance. Each 1-unit increase in LS7 score was associated with a 17% higher SPPB score (rate ratio (RR) = 1.17, 95% confidence interval (CI) = 1.15-1.19) and a 29% greater chance of having a late-life SPPB score of 10 or greater compared to SPPB score of less than 10 (RR = 1.29, 95% CI = 1.25-1.34). Ideal baseline glucose (RR = 2.53, 95% CI = 2.24-2.87), smoking (RR = 1.97, 95% CI = 1.81-2.15), blood pressure (RR = 1.70, 95% CI = 1.54-1.88), body mass index (RR = 1.51, 95% CI = 1.37-1.66), and physical activity (RR = 1.31, 95% CI = 1.20-1.43) had the strongest associations with late-life SPPB score, adjusting for other LS7 components.
conclusionBetter cardiovascular health during midlife may lead better physical functioning in older age.
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