ArticleScientific reports2017
Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Integrated Transcriptomics and Metabolomics with Machine Learning Identify Flavonoids as Key Effectors in Wheat Root Thermotolerance.Plants (Basel, Switzerland) · 2026Article
- Single Cell Multiomics of Hooked Potato Stolons Reveals Parallels to Shoot Apical Meristems in Arabidopsis.Plant biotechnology journal · 2026Article
- Tomato pollen tube growth requires flavonol glycosylation.Plant physiology · 2025Article
- Integrated Transcriptomic and Metabolomic Analysis Reveals Tissue-Specific Flavonoid Biosynthesis and MYB-Mediated Regulation of UGT71A1 inInternational journal of molecular sciences · 2025Article
- The role of mediator subunit MED7 in Arabidopsis development.Frontiers in plant science · 2025Article
- Genetic diversity, stress tolerance and phytobeneficial potential in rhizobacteria of Vachellia tortilis subsp. raddiana.Environmental microbiome · 2024Article
- Integrated metabolome and transcriptome analysis provide insight into the biosynthesis of flavonoids inFrontiers in plant science · 2024Article
- Auxin efflux carrier PsPIN4 identified through genome-wide analysis as vital factor of petal abscission.Frontiers in plant science · 2024Article
- Flavonols modulate plant development, signaling, and stress responses.Current opinion in plant biology · 2023Review
- The Hydrophilic Loop ofInternational journal of molecular sciences · 2022Article
- A Talk between Flavonoids and Hormones to Reorient the Growth of Gymnosperms.International journal of molecular sciences · 2021Review
- GmPIN-dependent polar auxin transport is involved in soybean nodule development.The Plant cell · 2021Article
- Relationship between the Phenylpropanoid Pathway and Dwarfism ofInternational journal of molecular sciences · 2021Article
- The R2R3-MYB transcription factor MtMYB134 orchestrates flavonol biosynthesis in Medicago truncatula.Plant molecular biology · 2021Article
- Article
- Auxin and Root Gravitropism: Addressing Basic Cellular Processes by Exploiting a Defined Growth Response.International journal of molecular sciences · 2021Review
- Flavonol-mediated stabilization of PIN efflux complexes regulates polar auxin transport.The EMBO journal · 2021Article
- Dynamic Transcriptomic and Metabolomic Analyses ofFrontiers in plant science · 2021Article
- Transcriptome and metabolite analyses provide insights into zigzag-shaped stem formation in tea plants (Camellia sinensis).BMC plant biology · 2020Article
- Increased Flavonol Levels in Tobacco ExpressingInternational journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phytohormone auxin is a major determinant and regulatory component important for plant development. Auxin transport between cells is mediated by a complex system of transporters such as AUX1/LAX, PIN, and ABCB proteins, and their localization and activity is thought to be influenced by phosphatases and kinases. Flavonols have been shown to alter auxin transport activity and changes in flavonol accumulation in the Arabidopsis thaliana rol1-2 mutant cause defects in auxin transport and seedling development. A new mutation in ROOTS CURL IN NPA 1 (RCN1), encoding a regulatory subunit of the phosphatase PP2A, was found to suppress the growth defects of rol1-2 without changing the flavonol content. rol1-2 rcn1-3 double mutants show wild type-like auxin transport activity while levels of free auxin are not affected by rcn1-3. In the rol1-2 mutant, PIN2 shows a flavonol-induced basal-to-apical shift in polar localization which is reversed in the rol1-2 rcn1-3 to basal localization. In vivo analysis of PINOID action, a kinase known to influence PIN protein localization in a PP2A-antagonistic manner, revealed a negative impact of flavonols on PINOID activity. Together, these data suggest that flavonols affect auxin transport by modifying the antagonistic kinase/phosphatase equilibrium.
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