ArticleScientific reports2017
Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Pilot investigation: randomized-controlled analog trial for alcohol and tobacco smoking co-addiction using contingency management.Behavioural pharmacology · 2018Trial
- Factors influencing tobacco smoking among men aged 15-49 years in Nepal.Scientific reports · 2025Article
- A case control study investigating the methylation levels of GHRL and GHSR genes in alcohol use disorder.Molecular biology reports · 2024Article
- Article
- Article
- Epigenetics of alcohol use disorder-A review of recent advances in DNA methylation profiling.Addiction biology · 2021Review
- Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation.Molecular psychiatry · 2021Article
- DRD2 methylation is associated with executive control network connectivity and severity of alcohol problems among a sample of polysubstance users.Addiction biology · 2020Article
- Epigenetic pharmacotherapy for substance use disorder.Biochemical pharmacology · 2019Review
- Brain Imaging-Guided Analysis Reveals DNA Methylation Profiles Correlated with Insular Surface Area and Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2019Article
- Isobaric Tag-Based Protein Profiling of a Nicotine-Treated Alpha7 Nicotinic Receptor-Null Human Haploid Cell Line.Proteomics · 2018Article
- Epigenomes in Cardiovascular Disease.Circulation research · 2018Review
- Effectiveness of smoking cessation intervention in opioid-dependent male subjects on buprenorphine maintenance treatment: An open-label trial.Industrial psychiatry journalArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Altered DNA methylation in addiction-related genes may modify the susceptibility to alcohol or drug dependence (AD or ND). We profiled peripheral blood DNA methylation levels of 384 CpGs in promoter regions of 82 addiction-related genes in 256 African Americans (AAs) (117 cases with AD-ND codependence and 139 controls) and 196 European Americans (103 cases with AD-ND codependence and 93 controls) using Illumina's GoldenGate DNA methylation array assays. AD-ND codependence-associated DNA methylation changes were analyzed using linear mixed-effects models with consideration of batch effects and covariates age, sex, and ancestry proportions. Seventy CpGs (in 41 genes) showed nominally significant associations (P < 0.05) with AD-ND codependence in both AAs and EAs. One CpG (HTR2B cg27531267) was hypomethylated in AA cases (P = 7.2 × 10
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.