ArticleNature medicine2017
α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.
Article in Nature medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06242535 (Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Outcomes of Paediatric Cystine Stone Management: Results of a Systematic Review.Current urology reports · 2023Pooled it
- Metabolic changes in kidney stone disease.Frontiers in immunology · 2023Pooled it
- Molecular Basis of Rare Inherited Tubulopathies of the Kidney: A Primer for Clinicians.International journal of molecular sciences · 2026Review
- Review
- Cystinuria in children: diagnosis and treatment.World journal of urology · 2025Review
- Alpha-lipoic acid, as an effective agent against toxic elements: a review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Mechanisms involved in aminoacidurias: impacts of genetic and environmental factors.Current research in physiology · 2025Review
- Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen.Journal of cellular and molecular medicine · 2024Review
- Review of childhood genetic nephrolithiasis and nephrocalcinosis.Frontiers in genetics · 2024Review
- Chemical Modification of Tiopronin for Dual Management of Cystinuria and Associated Bacterial Infections.ACS applied materials & interfaces · 2023Article
- The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9Redox biology · 2023Article
- A Summary of Current Guidelines and Future Directions for Medical Management and Monitoring of Patients with Cystinuria.Healthcare (Basel, Switzerland) · 2023Article
- Article
- Cystinuria: an update on pathophysiology, genetics, and clinical management.Pediatric nephrology (Berlin, Germany) · 2022Review
- Cystinuria: An Overview of Diagnosis and Medical Management.Turkish archives of pediatrics · 2022Article
- Differences in renal cortex transcriptional profiling of wild-type and novel type B cystinuria model rats.Urolithiasis · 2022Article
- CaNature communications · 2022Article
- S-Methyl-L-Ergothioneine to L-Ergothioneine Ratio in Urine Is a Marker of Cystine Lithiasis in a Cystinuria Mouse Model.Antioxidants (Basel, Switzerland) · 2021Article
- Cystinuria in Dogs and Cats: What Do We Know after Almost 200 Years?Animals : an open access journal from MDPI · 2021Review
- Evaluation and Medical Management of Patients with Cystine Nephrolithiasis: A Consensus Statement.Journal of endourology · 2020Article
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Authors and funding
19 authors at 5 institutions in 1 country.
Funding
Abstract
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.