Evidence map›Paper›PMID 28165468›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2017

Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution.

Xiaoqiu Liu, Simon S Wong, Carmen A Taype, Jeeyeon Kim, Tzu-Pin Shentu, Celia R Espinoza, J Cameron Finley, John E Bradley, Brian P Head, Hemal H Patel and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
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  13. Role and mechanism of CD90Molecular medicine (Cambridge, Mass.) · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Thy-1-Integrin Interactions inFrontiers in cell and developmental biology · 2022
    Review
  19. Review
  20. Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Xiaoqiu LiuRespiratory Department, Second Hospital of Jilin University, Changchun, China.
Simon S WongDivision of Respiratory Medicine, Department of Pediatrics, University of California San Diego, San Diego, CA, USA.
Carmen A TaypeDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Jeeyeon KimDepartment of Pediatrics, Stanford University, Palo Alto, CA, USA.
Tzu-Pin ShentuDivision of Respiratory Medicine, Department of Pediatrics, University of California San Diego, San Diego, CA, USA.
Celia R EspinozaDivision of Respiratory Medicine, Department of Pediatrics, University of California San Diego, San Diego, CA, USA.
J Cameron FinleyDepartment of Anesthesiology, UCSD, San Diego, CA, USA.
John E BradleyDepartment of Microbiology, University of Alabama-Birmingham, Birmingham, AL, USA.
Brian P HeadDepartment of Anesthesiology, UCSD, San Diego, CA, USA.
Hemal H PatelDepartment of Anesthesiology, UCSD, San Diego, CA, USA.
Emma J MahDepartment of Chemical and Biochemical Engineering, University of California-Irvine, Irvine, CA, USA.
James S HagoodDivision of Respiratory Medicine, Department of Pediatrics, University of California San Diego, San Diego, CA, USA.
University of California San Diego · USPalo Alto University · USSecond Affiliated Hospital of Jilin University · CNUniversity of Alabama at Birmingham · USUniversity of California, Irvine · US

Funding

Targeting the Apoptosis-Resistant Pulmonary MyofibroblastR01HL111169 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAGOOD, JAMES S. · 2012 to 2015
$1.7M
NHLBI NIH HHS R01 HL111169
6 · The paper itself

Abstract

Thy-1-negative lung fibroblasts are resistant to apoptosis. The mechanisms governing this process and its relevance to fibrotic remodeling remain poorly understood. By using either sorted or transfected lung fibroblasts, we found that Thy-1 expression is associated with downregulation of anti-apoptotic molecules Bcl-2 and Bcl-xL, as well as increased levels of cleaved caspase-9. Addition of rhFasL and staurosporine, well-known apoptosis inducers, caused significantly increased cleaved caspase-3, -8, and PARP in Thy-1-transfected cells. Furthermore, rhFasL induced Fas translocation into lipid rafts and its colocalization with Thy-1. These in vitro results indicate that Thy-1, in a manner dependent upon its glycophosphatidylinositol anchor and lipid raft localization, regulates apoptosis in lung fibroblasts via Fas-, Bcl-, and caspase-dependent pathways. In vivo, Thy-1 deficient (Thy1

Indexed as

AnimalsApoptosisbcl-X ProteinBleomycinCaspase 9Cell LineEmbryo, MammalianFas Ligand Proteinfas ReceptorFibroblastsImmunoblottingLung InjuryMembrane MicrodomainsMice, Inbred C57BLMice, KnockoutMicroscopy, Confocalbcl-X ProteinBleomycinCaspase 9Fas Ligand Proteinfas ReceptorProto-Oncogene Proteins c-bcl-2StaurosporineThy-1 Antigens

Identifiers

PMID28165468
PMCPMC5663248
OpenAlexW2587396893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.