Evidence map›Paper›PMID 28165464›Full record

ArticleNature communications2017

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

Philip J Law, Sonja I Berndt, Helen E Speedy, Nicola J Camp, Georgina P Sava, Christine F Skibola, Amy Holroyd, Vijai Joseph, Nicola J Sunter, Alexandra Nieters and 87 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Navigating primary and secondary immunodeficiency intersections: how to find IEI hidden within SID.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Review
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  20. Chromoanagenesis Detection in Chronic Lymphocytic Leukemia.Methods in molecular biology (Clifton, N.J.) · 2025
    Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

97 authors.

Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.ORCID 0000-0001-9663-4611
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Helen E SpeedyDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Nicola J CampDepartment of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Georgina P SavaDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Christine F SkibolaDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Amy HolroydDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Vijai JosephDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0002-7933-151X
Nicola J SunterNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Alexandra NietersCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany.
Silvia BeaInstitut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.
Alain MonnereauRegistre des hémopathies malignes de la Gironde, Institut Bergonié, Inserm U1219 EPICENE, 33076 Bordeaux, France.
David Martin-GarciaInstitut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.
Lynn R GoldinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Guillem ClotInstitut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.
Lauren R TerasEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Inés QuintelaGrupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.
Brenda M BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Sandrine JayneErnest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.
Wendy CozenDepartment of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Aneela MajidErnest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.
Karin E SmedbyUnit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Hematology Center, Karolinsak University Hospital, Stockholm 17176, Sweden.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Claire DeardenThe Royal Marsden NHS Foundation Trust, London SM2 5PT, UK.
Angela R Brooks-WilsonGenome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.
Andrew G HallNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Tryfonia Mainou-FowlerHaematological Sciences, Medical School, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK.
Claire M VajdicCentre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia.ORCID 0000-0002-3612-8298
Graham H JacksonDepartment of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
Pierluigi CoccoDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy.
Helen MarrNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Yawei ZhangDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.
Tongzhang ZhengDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Charles LawrenceWestat, Rockville, Maryland 20850, USA.
Timothy G CallDivision of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Mark LiebowDepartment of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Mads MelbyeDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.
Bengt GlimeliusDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.
Larry MansouriDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.
Martha GlennDepartment of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Karen CurtinDepartment of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
W Ryan DiverEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Brian K LinkDepartment of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.
Lucia CondeDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.
Rebecca D JacksonDivision of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, Ohio 43210, USA.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.
Yolanda BenaventeCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.
Paolo BoffettaThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Paul BrennanInternational Agency for Research on Cancer, Lyon 69372, France.
Marc MaynadieRegistre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France.
James McKayInternational Agency for Research on Cancer, Lyon 69372, France.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Zhaoming WangDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Lindsay M MortonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Richard K SeversonDepartment of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.
Elio RiboliSchool of Public Health, Imperial College London, London W2 1PG, UK.
Paolo VineisMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
Roel C H VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, The Netherlands.
Melissa C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.
Roger L MilneCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.ORCID 0000-0001-5764-7268
Jacqueline ClavelEpidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris F-94807, France.
Sabine TopkaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
John J SpinelliCancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Maria Grazia EnnasDepartment of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy.
Geoffrey SummerfieldDepartment of Haematology, Queen Elizabeth Hospital, Gateshead NE9 6SX, UK.
Giovanni M FerriInterdisciplinary Department of Medicine, University of Bari, Bari 70124, Italy.
Robert J HarrisDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK.
Lucia MiligiEnvironmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence 50139, Italy.
Andrew R PettittDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
David J AllsupQueens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK.ORCID 0000-0001-6159-6109
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
James R BaileyQueens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK.
Kenneth OffitDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Guy PrattDepartment of Haematology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.
Henrik HjalgrimDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.
Chris PepperDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Chris FeganCardiff and Vale National Health Service Trust, Heath Park, Cardiff CF14 4XW, UK.
Richard RosenquistDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.
Silvia de SanjoseThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Angel CarracedoGrupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.
Martin J S DyerErnest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.
Daniel CatovskyDivision of Molecular Pathology, The Institute of Cancer Research, London SW7 3RP, UK.
Elias CampoInstitut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.ORCID 0000-0001-9850-9793
James R CerhanDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
James M AllanNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Nathanial RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Richard HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Susan SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1M
CALIFORNIA'S PARTICIPATION IN THE NATIONAL CANCER PREVENTION AND CONTRO PROGRAMU58DP000807 · DP · PUBLIC HEALTH INSTITUTE · PI SNIPES, KURT P · 2007 to 2011
$22.5M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
CCR NIH HHS N01 RC037004NCATS NIH HHS KL2 TR001862NCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1 TR001863NCCDPHP CDC HHS U58 DP000807NCI NIH HHS HHSN261201000006CNCI NIH HHS HHSN261201000026CNCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS K08 CA134919NCI NIH HHS N01 CN045165NCI NIH HHS N01 CO012400NCI NIH HHS N01 PC065064NCI NIH HHS N01 PC067008NCI NIH HHS N01 PC067009NCI NIH HHS N01 PC067010NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA042014NCI NIH HHS P30 CA086862NCI NIH HHS P50 CA097274NCI NIH HHS R01 CA045614NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA062006NCI NIH HHS R01 CA087014NCI NIH HHS R01 CA092153NCI NIH HHS R01 CA098122NCI NIH HHS R01 CA098661NCI NIH HHS R01 CA134674NCI NIH HHS R01 CA148690NCI NIH HHS R01 CA149445NCI NIH HHS R01 CA154643NCI NIH HHS R03 CA089745NCI NIH HHS R21 CA165923NCI NIH HHS R21 CA178800NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA118444NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG007033NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIEHS NIH HHS P30 ES000260Wellcome TrustWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004CWorld Health Organization 001
6 · The paper itself

Abstract

Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10

Indexed as

Genetic Predisposition to DiseaseAdultAntibody FormationB-LymphocytesCase-Control StudiesChromosome MappingChromosomes, HumanFemaleGenome-Wide Association StudyHumansLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedPolymorphism, Single NucleotideYoung Adult

Identifiers

PMID28165464
PMCPMC5303820

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.