ReviewThe Journal of clinical investigation2017
Nuclear receptors: emerging drug targets for parasitic diseases.
Review in The Journal of clinical investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Conservation of Nuclear Receptor DAF-12 with Evidence for Ligand Diversification in Plant-Parasitic Nematodes.bioRxiv : the preprint server for biology · 2026Article
- Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes.PLoS pathogens · 2026Article
- Structure-guided screening of FAR-1 antagonists with multi-stage anthelmintic activity.Antimicrobial agents and chemotherapy · 2026Article
- Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.Signal transduction and targeted therapy · 2025Review
- Nuclear receptors as potential therapeutic targets in peripheral arterial disease and related myopathy.The FEBS journal · 2023Review
- Dimerization, host-parasite communication and expression studies of an Echinococcus granulosus 2DBD nuclear receptor.Parasitology research · 2023Article
- Filarial DAF-12 sense the host serum to resume iL3 development during infection.PLoS pathogens · 2023Article
- Molecular Cloning and Characterization of aPathogens (Basel, Switzerland) · 2022Article
- Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent ineLife · 2021Article
- Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasiteProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Transcription Factors Interplay Orchestrates the Immune-Metabolic Response ofFrontiers in cellular and infection microbiology · 2021Review
- The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF-12.Scientific reports · 2020Article
- Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism.PLoS pathogens · 2019Article
- Dauer signalling pathway model for Haemonchus contortus.Parasites & vectors · 2019Article
- Comparative bioinformatic analysis suggests that specific dauer-like signalling pathway components regulate Toxocara canis development and migration in the mammalian host.Parasites & vectors · 2019Article
- Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Parasitic worms infect billions of people worldwide. Current treatments rely on a small group of drugs that have been used for decades. A shortcoming of these drugs is their inability to target the intractable infectious stage of the parasite. As well-known therapeutic targets in mammals, nuclear receptors have begun to be studied in parasitic worms, where they are widely distributed and play key roles in governing metabolic and developmental transcriptional networks. One such nuclear receptor is DAF-12, which is required for normal nematode development, including the all-important infectious stage. Here we review the emerging literature that implicates DAF-12 and potentially other nuclear receptors as novel anthelmintic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.