ArticleScientific reports2017
The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Gallbladder removal induces hepatic transcriptional and metabolic shifts with cholesterol dysregulation as a key feature.Scientific reports · 2026Article
- Influence of LDL cholesterol and Lp(a) on monocytes and macrophages in atherosclerosis.Biochemia medica · 2025Review
- Review
- Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.Endocrinology · 2024Article
- Association of ABCG5 and ABCG8 Transporters with Sitosterolemia.Advances in experimental medicine and biology · 2024Review
- Circular RNA circ_0001445 alleviates the ox-LDL-induced endothelial injury in human primary aortic endothelial cells through regulating ABCG1 via acting as a sponge of miR-208b-5p.General thoracic and cardiovascular surgery · 2022Article
- Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release.International journal of molecular sciences · 2022Article
- Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins.Cellular & molecular immunology · 2022Review
- The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.Molecular oncology · 2021Article
- Mechanisms and regulation of cholesterol homeostasis.Nature reviews. Molecular cell biology · 2020Review
- The impact of ATP-binding cassette transporters on metabolic diseases.Nutrition & metabolism · 2020Review
- Do ABC transporters regulate plasma membrane organization?Cellular & molecular biology letters · 2020Review
- ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion.Biochemical Society transactions · 2019Review
- Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis.Journal of lipids · 2018Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ATP-binding cassette sub-family G member 1 (ABCG1) exports cellular cholesterol to high-density lipoproteins (HDL). However, a number of recent studies have suggested ABCG1 is predominantly localised to intracellular membranes. In this study, we found that ABCG1 was organized into two distinct cellular pools: one at the plasma membrane and the other associated with the endoplasmic reticulum (ER). The plasma membrane fraction was organized into filamentous structures that were associated with cortical actin filaments. Inhibition of actin polymerization resulted in complete disruption of ABCG1 filaments. Cholesterol loading of the cells increased the formation of the filamentous ABCG1, the proximity of filamentous ABCG1 to actin filaments and the diffusion rate of membrane associated ABCG1. Our findings suggest that the actin cytoskeleton plays a critical role in the plasma membrane localization of ABCG1.
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