Evidence map›Paper›PMID 28164771›Full record

ArticleCurrent Alzheimer research2017

A Role of the Parasympathetic Nervous System in Cognitive Training.

Feng Lin, Kathi L Heffner, Ping Ren, Duje Tadin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current Alzheimer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  13. Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory.Proceedings of the National Academy of Sciences of the United States of America · 2022
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  17. Competitive dynamics underlie cognitive improvements during sleep.Proceedings of the National Academy of Sciences of the United States of America · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Feng LinSchool of Nursing, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY 14642, United States.
Kathi L HeffnerDept. of Psychiatry, School of Medicine and Dentistry, University of Rochester Medical, Center, Rochester, NY 14642, United States.
Ping RenSchool of Nursing, University of Rochester Medical Center, Rochester, NY 14642, United States.
Duje TadinDept. of Brain & Cognitive Sciences, University of Rochester, Rochester, NY 14642, United States.
University of Rochester Medical Center · USUniversity of Rochester · US

Funding

Targeting Autonomic Flexibility to Enhance Cognitive Training Outcomes in Older Adults with Mild Cognitive ImpairmentR01NR015452 · NINR · UNIVERSITY OF ROCHESTER · PI HEFFNER, KATHI L, LIN, FENG VANKEE · 2015 to 2024
$4.4M
The University of Rochester Clinical and Translational Science InstituteKL2TR000095 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$1.7M
NCATS NIH HHS KL2 TR000095NINR NIH HHS R01 NR015452
6 · The paper itself

Abstract

backgroundVision-based speed of processing (VSOP) training can result in broad cognitive improvements in older adults with amnestic mild cognitive impairment (aMCI). What remains unknown, however, is what neurophysiological mechanisms account for the observed training effect. Much of the work in this area has focused on the central nervous system, neglecting the fact that the peripheral system can contributes to changes of the central nervous system and vice versa.

objectiveWe examined the prospective relationship between an adaptive parasympathetic nervous system response to cognitive stimuli and VSOP training-induced plasticity.

methodTwenty-one participants with aMCI (10 for VSOP training, and 11 for mental leisure activities (MLA) control) were enrolled. We assessed high-frequency heart rate variability (HF-HRV) during training sessions, and striatum-related neural networks and cognition at baseline and post-training.

resultsCompared to MLA, the VSOP group showed a significant U-shaped pattern of HF-HRV response during training, as well as decreases in connectivity strength between bilateral striatal and prefrontal regions. These two effects were associated with training-induced improvements in both the trained (attention and processing speed) and transferred (working memory) cognitive domains.

conclusionThis work provides novel support for interactions between the central and the peripheral nervous systems in relation to cognitive training, and motivates further studies to elucidate the causality of the observed link.

Indexed as

AgedAged, 80 and overAttentionCognitive Behavioral TherapyCognitive DysfunctionCorpus StriatumElectrocardiographyFemaleHeart RateHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysNeuropsychological Testsamnestic mild cognitive impairmentcognitive trainingParasympathetic nervous systemprocessing speedstriatumworking memory

Identifiers

PMID28164771
PMCPMC5530077
OpenAlexW2590568549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.