Evidence map›Paper›PMID 28164731›Full record

Trial reportPharmaceutical biology2017

Regulatory/modulatory effect of prune essence concentrate on intestinal function and blood lipids.

Hui-Fang Chiu, Yun-Chien Huang, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Oksana Golovinskaia, Kamesh Venkatakrishnan, Chin-Kun Wang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
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  12. Osteoarthritis Is a Low-Grade Inflammatory Disease: Obesity's Involvement and Herbal Treatment.Evidence-based complementary and alternative medicine : eCAM · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hui-Fang Chiua Department of Chinese Medicine , Taichung Hospital, Ministry of Health and Well-being , Taichung , Taiwan , ROC.
Yun-Chien Huangb School of Nutrition , Chung Shan Medical University , Taichung City , Taiwan , ROC.
Yan-Ying Luc Department of Neurology , Chung Shan Medical University , Taichung City , Taiwan , ROC.
Yi-Chun Hanb School of Nutrition , Chung Shan Medical University , Taichung City , Taiwan , ROC.
You-Cheng Shend School of Health Diet and Industry Management , Chung Shan Medical University , Taichung City , Taiwan , ROC.
Oksana Golovinskaiae ITMO University , Saint-Peterburg , Russia.
Kamesh Venkatakrishnanb School of Nutrition , Chung Shan Medical University , Taichung City , Taiwan , ROC.
Chin-Kun Wangb School of Nutrition , Chung Shan Medical University , Taichung City , Taiwan , ROC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextPrunus domestica Linn (Rosaceae) has been considered a functional food, owing to its various pharmacological activities, including antioxidant, anti-inflammatory, antidiabetic and anticancer.

objectiveThis placebo-controlled, randomized study was framed to check the beneficial activity of prune essence concentrates (PEC) in corroboration with intestinal function and lipid profile in mildly hypercholesterolemic subjects. MATERIALS AND

methodsSixty healthy mild hypercholesterolemic subjects were randomly chosen and segregated into three groups as placebo (consume 50 mL of simulated prune drink), PEC I (consume 50 mL of PEC/day) and PEC II (consume 100 mL of PEC/day) for 4 weeks with 2 weeks of follow-up without PEC consumption.

resultsIntake of PEC (I and II) for 4 weeks substantially ameliorated (p < 0.05) the colony number of Bifidobacterium spp. (1.18- and 1.19-fold) and Lactobacillus spp. (1.07- and 1.16-fold), but markedly lowered (p < 0.05) the colony number of Clostridium perfringens (5.97 and 8.35%) and Escherichia coli (6.25 and 9.38%). Meanwhile, the total cholesterol (TC; 5.90 and 6.99%) levels and LDL-c (6.68 and 6.53%) were significantly reduced (p < 0.05), but no change in other lipid parameters. Whereas, the antioxidant capacity was also concomitantly elevated (p < 0.05) upon administration with PEC. DISCUSSION AND

conclusionOverall, the results suggest that the use of PEC may positively regulate the intestinal microflora and thereby effectively lower the TC levels and thus act as a hypocholesterolemic agent.

Indexed as

Fruit and Vegetable JuicesAdolescentAdultAnticholesteremic AgentsAntioxidantsBiomarkersCholesterol, LDLColony Count, MicrobialDown-RegulationFecesFemaleGastrointestinal AgentsGastrointestinal MicrobiomeHumansHypercholesterolemiaIntestinesAnticholesteremic AgentsAntioxidantsBiomarkersCholesterol, LDLGastrointestinal AgentsPlant ExtractsThiobarbituric Acid Reactive Substancesantioxidant capacityHypercholesterolemicintestinal microfloralipid profile

Identifiers

PMID28164731
PMCPMC6130511

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.