Evidence map›Paper›PMID 28164396›Full record

ArticleNMR in biomedicine2017

Improved multiparametric MRI discrimination between low-risk prostate cancer and benign tissues in a small cohort of 5α-reductase inhibitor treated individuals as compared with an untreated cohort.

Olga Starobinets, John Kurhanewicz, Susan M Noworolski

Abstract readControlled Clinical Trial
In one paragraph

Article in NMR in biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Olga StarobinetsGraduate Group in Bioengineering, UCSF and UC Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-6306-1439
John KurhanewiczGraduate Group in Bioengineering, UCSF and UC Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-3544-5339
Susan M NoworolskiGraduate Group in Bioengineering, UCSF and UC Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-1609-2790

Funding

Translation and Evaluation of a Multiparametric Prostate Cancer 3T ExamR01CA137207 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HURD, RALPH EUGENE, KURHANEWICZ, JOHN · 2010 to 2014
$2.6M
DCE MRI to Improve Prostate Cancer Identification and CharacterizationR01CA148708 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOWOROLSKI, SUSAN M · 2010 to 2014
$1.3M
NCI NIH HHS R01 CA137207NCI NIH HHS R01 CA148708
6 · The paper itself

Abstract

The purpose of this study was to determine whether 5α-reductase inhibitors (5-ARIs) affect the discrimination between low-grade prostate cancer and benign tissues on multiparametric MRI (mpMRI). Twenty men with biopsy-proven Gleason 3 + 3 prostate cancer and 3 T mpMRI were studied. Ten patients (Tx) had been receiving 5-ARIs for at least a year at scan time. Ten untreated patients (Un) were matched to the treated cohort. For each subject two regions of interest representing cancerous and benign tissues were drawn within the peripheral zone of each prostate, MR measures evaluated, and cancer contrast versus benign (contrast = (MR

Indexed as

Algorithms5-alpha Reductase InhibitorsAgedAntineoplastic AgentsCohort StudiesDiagnosis, DifferentialHormone Replacement TherapyHumansImage EnhancementMagnetic Resonance ImagingMaleMiddle AgedProstatic NeoplasmsReproducibility of ResultsRisk FactorsSensitivity and Specificity5-alpha Reductase InhibitorsAntineoplastic Agents5α-reductase inhibitorsdutasteridefinasteridempMRIprostate cancer

Identifiers

PMID28164396
PMCPMC5522750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.