ArticleGenome biology and evolution2017
Massive Expansion of Gypsy-Like Retrotransposons in Microbotryum Fungi.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Repeated loss of function at HD mating-type genes and of recombination in anther-smut fungi.Nature communications · 2025Article
- Comparative genome analysis and the genome-shaping role of long terminal repeat retrotransposons in the evolutionary divergence of fungal pathogens Blastomyces dermatitidis and Blastomyces gilchristii.G3 (Bethesda, Md.) · 2024Article
- Comparative Genomic Analyses ofJournal of fungi (Basel, Switzerland) · 2024Article
- Article
- Dynamics of transposable element accumulation in the non-recombining regions of mating-type chromosomes in anther-smut fungi.Nature communications · 2023Article
- Population genomics of transposable element activation in the highly repressive genome of an agricultural pathogen.Microbial genomics · 2021Article
- Austropuccinia psidii, causing myrtle rust, has a gigabase-sized genome shaped by transposable elements.G3 (Bethesda, Md.) · 2021Article
- Homology-Free Detection of Transposable Elements Unveils Their Dynamics in Three Ecologically DistinctGenes · 2020Article
- Advances in understanding the evolution of fungal genome architecture.F1000Research · 2020Review
- Multiple convergent supergene evolution events in mating-type chromosomes.Nature communications · 2018Article
- Sources of Fungal Genetic Variation and Associating It with Phenotypic Diversity.Microbiology spectrum · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposable elements (TEs) are selfish, autonomously replicating DNA sequences that constitute a major component of eukaryotic genomes and contribute to genome evolution through their movement and amplification. Many fungal genomes, including the anther-smut fungi in the basidiomycete genus Microbotryum, have genome defense mechanisms, such as repeat-induced point mutation (RIP), which hypermutate repetitive DNA and limit TE activity. Little is known about how hypermutation affects the tempo of TE activity and their sequence evolution. Here we report the identification of a massive burst-like expansion of Gypsy-like retrotransposons in a strain of Microbotryum. This TE expansion evidently occurred in the face of RIP-like hypermutation activity. By examining the fitness of individual TE insertion variants, we found that RIP-like mutations impair TE fitness and limit proliferation. Our results provide evidence for a punctuated pattern of TE expansion in a fungal genome, similar to that observed in animals and plants. While targeted hypermutation is often thought of as an effective protection against mobile element activity, our findings suggest that active TEs can persist and undergo selection while they proliferate in genomes that have RIP-like defenses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.