Evidence map›Paper›PMID 28164171›Full record

ArticlePathogens & immunity

Diminished CD103 (αEβ7) Expression on Resident T Cells from the Female Genital Tract of HIV-Positive Women.

David C Moylan, Paul A Goepfert, Mirjam-Colette Kempf, Michael S Saag, Holly E Richter, Jiri Mestecky, Steffanie Sabbaj

Open access · diamondAbstract read
In one paragraph

Article in Pathogens & immunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

  1. CD8MedComm · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Formation of Tissue-Resident CD8Cold Spring Harbor perspectives in biology · 2021
    Review
  8. Review
  9. Review
  10. Review
  11. Resident Memory T Cells and Their Role within the Liver.International journal of molecular sciences · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Changes of CD103-expressing pulmonary CD4BMC infectious diseases · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Aging impacts CD103Aging cell · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

David C MoylanDepartments of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Paul A GoepfertDepartments of Medicine, University of Alabama at Birmingham, Birmingham, AL; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL.
Mirjam-Colette KempfSchool of Nursing and Department of Health Behavior, University of Alabama at Birmingham, Birmingham, AL.
Michael S SaagDepartments of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Holly E RichterObstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL.
Jiri MesteckyDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL.
Steffanie SabbajDepartments of Medicine, University of Alabama at Birmingham, Birmingham, AL.
University of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
UAB-MISS WIHS CohortU01AI103401 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEMPF, MIRJAM-COLETTE, KONKLE-PARKER, DEBORAH J · 2013 to 2018
$11.2M
A novel source of mucosal T cells to study immunity in the female genital tractR21AI116320 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SABBAJ, STEFFANIE · 2015 to 2016
$403k
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454NCI NIH HHS P30 CA013148NIAID NIH HHS P30 AI027767NIAID NIH HHS R21 AI116320NIAID NIH HHS U01 AI103401
6 · The paper itself

Abstract

backgroundTissue resident memory T cells (TrM) provide an enhanced response against infection at mucosal surfaces, yet their function has not been extensively studied in humans, including the female genital tract (FGT).

methodsUsing polychromatic flow cytometry, we studied TrM cells, defined as CD62L-CCR7-CD103

resultsWe demonstrate that TrM are present in the FGT of healthy and HIV-positive women. The expression of the mucosal retention receptor, CD103, from HIV-positive women was reduced compared to healthy women and was lowest in women with CD4 counts < 500 cells/mm

conclusionsThese data suggest that CD4

Indexed as

CD103CD4 T cellsCD8+ T cellsfemale genital tractHIV-1mucosal immunityTissue Resident Memory T cells

Identifiers

PMID28164171
PMCPMC5288734
OpenAlexW2572456820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.