ArticleCardiovascular diagnosis and therapy2017
Epidemiological and mortality trends in infective endocarditis, a 17-year population-based prospective study.
Article in Cardiovascular diagnosis and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 6 of them syntheses that pooled it.
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Who cites it
136 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Infective endocarditis complicated by shock: a systematic review and meta-analysis.Heart failure reviews · 2025Pooled it
- Infective Endocarditis byPathogens (Basel, Switzerland) · 2025Pooled it
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- A comparison of different antibiotic regimens for the treatment of infective endocarditis.The Cochrane database of systematic reviews · 2020Pooled it
- Specialty-Related Differences in Adherence to Antibiotic Therapy Guidelines for Infective Endocarditis in Older Patients.Antibiotics (Basel, Switzerland) · 2026Article
- Impact of Adherence to Guideline-Recommended Surgical Timing on Outcomes in Infective Endocarditis.Journal of clinical medicine · 2026Article
- Impact of methicillin resistance on mortality in Staphylococcus aureus endocarditis: a systematic review and meta-analysis.Communications medicine · 2026Article
- A Rare Presentation of Infective Endocarditis Complicating Severe Aortic Valve Stenosis.Journal of cardiovascular development and disease · 2026Article
- Embolic Burden and Echocardiographic Predictors in a Real-World Cohort of Infective Endocarditis: A 15-Year Single-Center Retrospective Study.Journal of clinical medicine · 2026Article
- Real-World Infective Endocarditis in a Regional Hospital: Clinical Severity, Guideline Adherence, and Determinants of In-Hospital Outcomes.Journal of clinical medicine · 2026Article
- Long-term outcomes of mitral valve surgery in infective endocarditis: a single-centre UK experience.Open heart · 2026Article
- Development and validation of a machine learning model for predicting 6-month mortality in patients with infective endocarditis.Biomedical engineering online · 2026Article
- Trends and disparities in mortality from infective endocarditis in the United States, 1999-2023: a nationwide analysis.Frontiers in cardiovascular medicine · 2026Article
- Clinical Characteristics, Microbiology, and In-Hospital Outcomes of Infective Endocarditis at a Tertiary Cardiac Center in Saudi Arabia: A Retrospective Cohort Study.Journal of the Saudi Heart Association · 2026Article
- Indicators of In-Hospital Mortality in Infective Endocarditis: A Single-Center Retrospective Study.Cureus · 2026Article
- Infective endocarditis and relationship with diabetes mellitus - Patient characteristics, microbial etiology and mortality.Infection · 2025Article
- Clinical presentation, microbiological profile, and management challenges of infective endocarditis: a retrospective study from a high volume cardiac centre in Pakistan.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- Microbial Transitions in Infective Endocarditis Influence the Spectrum of Clinical Features and Functional Outcomes.Circulation reports · 2025Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
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Abstract
backgroundThe population at risk, the clinical and microbiological features of infective endocarditis (IE) have changed. Aim of our study was to evaluate the contemporary epidemiological trends, over a 17-year period in a definite region of Tuscany, Italy, to analyze the clinical outcomes and associated prognostic factors.
methodsFrom 1 January 1998 to 31 December 2014, all patients with a definite diagnosis of IE were prospectively entered in a data-base. The Health-Care system data-base was interrogated to capture patients who could have been missed. The final dataset derived by the merging of the two data-bases.
resultsIncidence rate of IE was 4.6/100,000/y with a significant linear incidence increase. In hospitalized patients the incidence was 1.27/1,000 admissions. Over age 65 incidence rate was 11.7/100,000/y. Male/female ratio was 1.54:1. A temporal trend towards an increase in the mean population age was found (P=0.033). There was an increase in the incidence of Health-care associated IE, P=0.016. The most common microorganisms were staphylococcus aureus (25%) and coagulase-negative staphylococci (22%). In-hospital mortality was 24%. A trend towards an increase in mortality rate was found (P=0.055). Independent predictors of mortality were older age, S. aureus infection, heart failure, septic shock and persistent bacteremia.
conclusionsOur study confirms an increasing mortality trend in IE, although with a borderline significance. Elderly forms are associated with poor prognosis and higher than 1-year mortality rate even in the multivariate analysis. Ageing population, increase in healthcare-associated and staphylococcal infections, may explain the rise of IE incidence and of the mortality trend.
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