Evidence map›Paper›PMID 28163820›Full record

ArticleOxidative medicine and cellular longevity2017

Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death.

Adriene A Paiva, Helena F Raposo, Amarylis C B A Wanschel, Tarlliza R Nardelli, Helena C F Oliveira

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. The Role of Hydrogen Sulfide Regulation of Autophagy in Liver Disorders.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Adriene A PaivaDepartment of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
Helena F RaposoDepartment of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
Amarylis C B A WanschelDepartment of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
Tarlliza R NardelliDepartment of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
Helena C F OliveiraDepartment of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.ORCID 0000-0003-0119-6992
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of liver disease in obesity and metabolic syndrome. By comparing hypertriglyceridemic transgenic mice expressing apolipoprotein (apo) CIII with control nontransgenic (NTg) littermates, we demonstrated that overexpression of apoCIII, independent of a high-fat diet (HFD), produces NAFLD-like features, including increased liver lipid content; decreased antioxidant power; increased expression of TNF

Indexed as

AnimalsApolipoprotein C-IIICell DeathDiet, High-FatHypertriglyceridemiaInflammationInterleukin-6MaleMiceMice, TransgenicNon-alcoholic Fatty Liver DiseaseSignal TransductionTumor Necrosis Factor-alphaApolipoprotein C-IIIInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID28163820
PMCPMC5259655
OpenAlexW2570433949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.