Evidence map›Paper›PMID 28163748›Full record

ArticleNutrition & metabolism2017

Weight loss technology for people with treated type 2 diabetes: a randomized controlled trial.

Kuat Oshakbayev, Bibazhar Dukenbayeva, Gulnar Togizbayeva, Aigul Durmanova, Meruyert Gazaliyeva, Abdul Sabir, Aliya Issa, Alisher Idrisov

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT02503865. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02503865 phase1 / phase2completed

Phase 1-2 Study of Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic Syndrome

Ran2003Enrolled351Registered outcomes5Posted comparisons0ConditionsMetabolic SyndromeArms"Analimentary detoxication", Xenical, Pionorm, Diroton, Diltiazem, Atorvastatin
PMID 22140269PMID 23176668PMID 23451166other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Kuat OshakbayevMetabolic Syndrome Department, Nazarbayev University Medical Center, Street Baitursynuly, 5, fl. 601, 010000 Astana, Kazakhstan.ORCID 0000-0003-4883-295X
Bibazhar DukenbayevaFaculty of Pathology and Forensic Medicine, Medical University Astana, Astana, Kazakhstan.
Gulnar TogizbayevaFaculty of Cardiology, Medical University Astana, Astana, Kazakhstan.
Aigul DurmanovaDepartment of Endocrinology, Republican Diagnostic Center at Nazarbayev University Medical Center, Astana, Kazakhstan.
Meruyert GazaliyevaFaculty of Internal Medicine, Karaganda State Medical University, Karaganda, Kazakhstan.
Abdul SabirNeurodevelopmental Services, Richmond Healthcare Civic Centre, Twickenham, London UK.
Aliya IssaDepartment of Endocrinology, National Scientific Cardiac Surgery Center, Astana, Kazakhstan.
Alisher IdrisovDepartment of Endocrinology, Medical University Astana, Astana, Kazakhstan.
Astana Medical University · KZNazarbayev University · KZKaraganda Medical University · KZNeuroDevelopment Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of type 2 diabetes is increasing in worldwide despite the development of new treatment methods. Aim of the study was to evaluate a weight loss method on body composition, glycemic, lipid and hormone profiles, blood pressure and reactive oxygen species in people with treated type 2 diabetes.

methodsA 24-week open, prospective, randomized, controlled clinical trial including 272 adult patients with treated type 2 diabetes was performed. The patients were divided in two groups: Main group consisted of 208 patients who followed a method including a calorie restriction diet and optimal physical activity; Control included 64 patients who received conventional drug treatment with weight loss. Main Outcome Measures were weight loss, fasting glucose and 2-hour oral glucose tolerance test (OGTT), HbA1c. Secondary endpoints were blood pressure, lipid and insulin blood levels.

resultsAt 24 weeks, patients in Main weight lost between 8-18 kg (10-21%); their body mass index significantly decreased (-4.2 kg/m2) as well as their waist circumference (-13 cm) compared to Control. In Main weight loss was achieved fatty mass reduction. In Main fasting glucose and OGTT, HbA1c, blood pressure, reactive oxygen species decreased significantly, whereas hemoglobin levels and heel bone mineral density increased. In Main blood insulin levels decreased by 72.0%, cortisol levels decreased by 40.7%, while testosterone levels in men increased by 2.4 times from baseline. The application of the weight loss method led to a decrease in drug doses leading to their complete withdrawal.

conclusionsThe results of this study show the beneficial role of a weight loss method in improving glycemic, lipid and hormone profiles, electrolyte and biochemical indices, blood pressure, reactive oxygen species and bone mineral density in patients with treated type 2 diabetes.

trial registrationClinicalTrials.gov Identifier: NCT02503865. Retrospectively registered November 2015.

Indexed as

Glycemic/lipid and hormone profilesLipid/protein oxidationRestriction dietType 2 diabetesWeight loss

Identifiers

PMID28163748
PMCPMC5286692
OpenAlexW2584749372

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.