Evidence map›Paper›PMID 28163303›Full record

ReviewNature reviews. Immunology2017

Regulation of muscle growth and regeneration by the immune system.

James G Tidball

Abstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 470 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
470citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

470 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Effect ofNutrients · 2024
    Trial
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  9. Review
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  12. Targeting TGF-β to Attenuate Ischemia-Reperfusion Associated Muscle Fibrosis and Enhance Regeneration: A Preclinical Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

410 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James G TidballMolecular, Cellular and Integrative Physiology Program, University of California, Los Angeles, California 90095-1606, USA.

Funding

Myeloid-cell mediated mechanisms driving muscle growth and regenerationR01AR066036 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2014 to 2018
$1.8M
Immune cell regulation of the regeneration of dystrophic muscleR01AR062579 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2014 to 2018
$1.7M
Functions of myelomonocytic lineage cells in aging muscleR01AG041147 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2011 to 2015
$1.7M
Targeting Therapeutic Molecules to Dystrophic Muscle via the Immune SystemR21AR066817 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2014 to 2015
$373k
NIAMS NIH HHS R01 AR062579NIAMS NIH HHS R01 AR066036NIAMS NIH HHS R21 AR066817NIA NIH HHS R01 AG041147
6 · The paper itself

Abstract

Diseases of muscle that are caused by pathological interactions between muscle and the immune system are devastating, but rare. However, muscle injuries that involve trauma and regeneration are fairly common, and inflammation is a clear feature of the regenerative process. Investigations of the inflammatory response to muscle injury have now revealed that the apparently nonspecific inflammatory response to trauma is actually a complex and coordinated interaction between muscle and the immune system that determines the success or failure of tissue regeneration.

Indexed as

AnimalsHumansMuscle, SkeletalRegeneration

Identifiers

PMID28163303
PMCPMC5452982

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.