Evidence map›Paper›PMID 28163219›Full record

ArticleMetabolic engineering2017

Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics.

Andrew N Lane, Julie Tan, Yali Wang, Jun Yan, Richard M Higashi, Teresa W-M Fan

Abstract read
In one paragraph

Article in Metabolic engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
  2. Article
  3. NMR-Based Stable Isotope Tracing of Cancer Metabolism.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Plant Metabolomics: The Future of Anticancer Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. International journal of molecular sciences · 2023
    Article
  9. Quantitative NMR Methods in Metabolomics.Handbook of experimental pharmacology · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. NMR-Based Metabolomics.Advances in experimental medicine and biology · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew N LaneJ.G. Brown Cancer Center, University of Louisville, Louisville, KY, United States; Dept. Chemistry and Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY, United States. Electronic address: andrew.lane@uky.edu.
Julie TanJ.G. Brown Cancer Center, University of Louisville, Louisville, KY, United States. Electronic address: jinlian.tan@louisville.edu.
Yali WangJ.G. Brown Cancer Center, University of Louisville, Louisville, KY, United States. Electronic address: yali.wang@louisville.edu.
Jun YanJ.G. Brown Cancer Center, University of Louisville, Louisville, KY, United States.
Richard M HigashiDept. Chemistry and Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY, United States.
Teresa W-M FanJ.G. Brown Cancer Center, University of Louisville, Louisville, KY, United States; Dept. Chemistry and Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY, United States. Electronic address: twmfan@gmail.com.

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3M
SAMPLE COREU24DK097215 · NIDDK · UNIVERSITY OF KENTUCKY · PI FAN, TERESA WHEI-MEI, HIGASHI, RICHARD M · 2013 to 2017
$8.7M
Stable isotopomer analysis of anabolic metabolic pathways in breast cancerR21CA133668 · NCI · UNIVERSITY OF LOUISVILLE · PI LANE, ANDREW N. · 2009 to 2010
$358k
NCI NIH HHS P30 CA177558NCI NIH HHS R21 CA133668NIDDK NIH HHS U24 DK097215
6 · The paper itself

Abstract

Breast cancers vary by their origin and specific set of genetic lesions, which gives rise to distinct phenotypes and differential response to targeted and untargeted chemotherapies. To explore the functional differences of different breast cell types, we performed Stable Isotope Resolved Metabolomics (SIRM) studies of one primary breast (HMEC) and three breast cancer cells (MCF-7, MDAMB-231, and ZR75-1) having distinct genotypes and growth characteristics, using

Indexed as

Metabolic Networks and PathwaysAnimalsBreast NeoplasmsFemaleHeterograftsHumansIsotope LabelingMCF-7 CellsMetabolomicsMiceMice, Inbred NODMice, SCIDNeoplasm Transplantation(13)C(3)-glycerol(13)C(3)-glycerol (PubChem CID:753)(13)C(5)(13)C(5),(15)N(2)-Glutamine (PubChem CID:5961)(13)C(6)-glucose(13)C(6)-glucose (PubChem CID:5793)(13)C(8)-octanoate(13)C(8)-octanoate (PubChem CID:11939)(15)N(2)-Gln1D/2D NMRalanine (PubChem CID:5950)aspartate (PubChem CID:5460541)ATPBreast cancer metabolismFT-ICR-MSglutamate (PubChem CID:5128032)lactate (PubChem CID:91435)Mouse xenografts(PubChem CID:5927)Stable isotope-resolved metabolomicsUTP(PubChem CID:6133)

Identifiers

PMID28163219
PMCPMC5540847

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.