Evidence map›Paper›PMID 28163160›Full record

ArticleExperimental neurology2017

Transplanted human glial-restricted progenitors can rescue the survival of dysmyelinated mice independent of the production of mature, compact myelin.

Agatha Lyczek, Antje Arnold, Jiangyang Zhang, James T Campanelli, Miroslaw Janowski, Jeff W M Bulte, Piotr Walczak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
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  11. ACS applied materials & interfaces · 2021
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  17. Advanced functional materials · 2019
    Article
  18. Article
  19. Article
  20. Poster Viewing Sessions PB01-B01 to PB03-V09.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Agatha LyczekRussell H. Morgan Dept. of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD 21205, United States.
Antje ArnoldRussell H. Morgan Dept. of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD 21205, United States.
Jiangyang ZhangRussell H. Morgan Dept. of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States.
James T CampanelliQ Therapeutics, Inc., Salt Lake City, UT 84108, United States.
Miroslaw JanowskiRussell H. Morgan Dept. of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD 21205, United States; Dept. of Neurosurgery, Mossakowski Med. Res. Center, Polish Acad. of Sci., Warsaw, Poland; Dept. of NeuroRepair, Mossakowski Med. Res. Center, Polish Acad. of Sci., Warsaw, Poland.
Jeff W M BulteRussell H. Morgan Dept. of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD 21205, United States.
Piotr WalczakRussell H. Morgan Dept. of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD 21205, United States; Dept. of Neurology and Neurosurgery, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland. Electronic address: pwalczak@mri.jhu.edu.

Funding

Imaging Neonatal Hypoxic Ischemic InjuryR01HD074593 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FRANCES J NORTHINGTON, JIANGYANG ZHANG · 2013 to 2026
$6.8M
MR Tracking of Magnetically Labeled Stem Cells in CNSR01NS045062 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2003 to 2013
$4.4M
Treatment of ALS based on transplantation of glial restricted progenitorsR01NS091110 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WALCZAK, PIOTR · 2015 to 2019
$1.8M
Efficient Targeting of Therapeutic Cells in Stroke and EAER01NS076573 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WALCZAK, PIOTR · 2012 to 2016
$1.8M
Mapping gene expression in the developing mouse brainR01NS070909 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ZHANG, JIANGYANG · 2010 to 2014
$1.7M
NICHD NIH HHS R01 HD074593NINDS NIH HHS R01 NS045062NINDS NIH HHS R01 NS070909NINDS NIH HHS R01 NS076573NINDS NIH HHS R01 NS091110
6 · The paper itself

Abstract

The therapeutic effect of glial progenitor transplantation in diseases of dysmyelination is currently attributed to the formation of new myelin. Using magnetic resonance imaging (MRI), we show that the therapeutic outcome in dysmyelinated shiverer mice is dependent on the extent of cell migration but not the presence of mature and compact myelin. Human or mouse glial restricted progenitors (GRPs) were transplanted into rag2

Indexed as

Stem Cell TransplantationAnimalsBasic Helix-Loop-Helix ProteinsBrainCell DifferentiationCell MovementCell SurvivalDemyelinating DiseasesDisease Models, AnimalDNA-Binding ProteinsGangliosidesGlial Fibrillary Acidic ProteinHumansMiceMice, TransgenicMyelin Basic ProteinBasic Helix-Loop-Helix Proteinsbeta3 tubulin, mouseDNA-Binding Proteinsganglioside A2B5GangliosidesGlial Fibrillary Acidic ProteinMbp protein, mouseMyelin Basic ProteinMyelin Proteolipid ProteinNerve Tissue ProteinsOlig2 protein, mouseOligodendrocyte Transcription Factor 2Plp1 protein, mouseRag2 protein, mouseTubulinGlial progenitorsMRIMyelinShivererTransplantation

Identifiers

PMID28163160
PMCPMC5397299

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.