Evidence map›Paper›PMID 28163133›Full record

ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2017

How many blinks are necessary for a reliable startle response? A test using the NPU-threat task.

Lynne Lieberman, Elizabeth S Stevens, Carter J Funkhouser, Anna Weinberg, Casey Sarapas, Ashley A Huggins, Stewart A Shankman

Abstract read
In one paragraph

Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Trial
  2. Article
  3. Article
  4. Article
  5. Threat effects on attention networks in individuals with a history of externalizing behaviors.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023
    Article
  6. Article
  7. Fear Potentiated Startle in Children With Autism Spectrum Disorder: Association With Anxiety Symptoms and Amygdala Volume.Autism research : official journal of the International Society for Autism Research · 2021
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. The Impact of Alcohol and Social Context on the Startle Eyeblink Reflex.Alcoholism, clinical and experimental research · 2018
    Article
  13. Using Event-Related Potentials and Startle to Evaluate Time Course in Anxiety and Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lynne LiebermanUniversity of Illinois at Chicago, Department of Psychology, Chicago, IL 60657, United States.
Elizabeth S StevensUniversity of Illinois at Chicago, Department of Psychology, Chicago, IL 60657, United States.
Carter J FunkhouserUniversity of Illinois at Chicago, Department of Psychology, Chicago, IL 60657, United States.
Anna WeinbergMcGill University, Department of Psychology, Montreal, QB, Canada.
Casey SarapasUniversity of Illinois at Chicago, Department of Psychology, Chicago, IL 60657, United States.
Ashley A HugginsUniversity of Wisconsin, Department of Psychology, Milwaukee, WI 53211, United States.
Stewart A ShankmanUniversity of Illinois at Chicago, Department of Psychology, Chicago, IL 60657, United States. Electronic address: stewarts@uic.edu.

Funding

Family Study of Reward and Threat Sensitivity in Internalizing PsychopathologyR01MH098093 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHANKMAN, STEWART AARON · 2012 to 2015
$2.7M
Anticipating reward & threat: A test of biobehavioral processes in MDD vs anxietyR21MH080689 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHANKMAN, STEWART AARON · 2009 to 2010
$408k
NIMH NIH HHS R01 MH098093NIMH NIH HHS R21 MH080689
6 · The paper itself

Abstract

Emotion-modulated startle is a frequently used method in affective science. Although there is a growing literature on the reliability of this measure, it is presently unclear how many startle responses are necessary to obtain a reliable signal. The present study therefore evaluated the reliability of startle responding as a function of number of startle responses (NoS) during a widely used threat-of-shock paradigm, the NPU-threat task, in a clinical (N=205) and non-clinical (N=92) sample. In the clinical sample, internal consistency was also examined independently for healthy controls vs. those with panic disorder and/or major depression and retest reliability was assessed as a function of NoS. Although results varied somewhat by diagnosis and for retest reliability, the overall pattern of results suggested that six startle responses per condition were necessary to obtain acceptable reliability in clinical and non-clinical samples during this threat-of-shock paradigm in the present study.

Indexed as

AdultBlinkingFemaleHumansMajor Depressive DisorderMaleMiddle AgedPanic DisorderPsychometricsPsychophysiologyReflex, StartleReproducibility of ResultsYoung AdultAnxiety-potentiated startleEmotion-modulated startleEyeblink startle reflexFear-potentiated startleReliability

Identifiers

PMID28163133
PMCPMC5344746

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.