ReviewExperimental gerontology2017
Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases.
Review in Experimental gerontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Impact of sex differences on microglial function in Alzheimer's disease.Alzheimer's research & therapy · 2026Review
- Multimodal Free-Water Imaging Links Cardiometabolic Risk to Periarterial Dysfunction and Amyloid Accumulation in Early Alzheimer's.Research square · 2026Article
- TIPS in Older Adults: Reserve-Based Risk Stratification and Practical Approach.Journal of clinical medicine · 2026Review
- Preoperative Status of Gut Microbiota Predicts Postoperative Delirium in Patients With Gastric Cancer.Frontiers in psychiatry · 2022Article
- Chemically induced senescence in human stem cell-derived neurons promotes phenotypic presentation of neurodegeneration.Aging cell · 2022Article
- Brain Atrophy and White Matter Damage Linked to Peripheral Bioenergetic Deficits in the Neurodegenerative Disease FXTAS.International journal of molecular sciences · 2021Article
- Review
- The role and mechanisms of polycomb repressive complex 2 on the regulation of osteogenic and neurogenic differentiation of stem cells.Cell proliferation · 2021Review
- Lumbar spinal cord microglia exhibited increased activation in aging dogs compared with young adult dogs.GeroScience · 2020Article
- Plant-Derived Antioxidants Protect the Nervous System From Aging by Inhibiting Oxidative Stress.Frontiers in aging neuroscience · 2020Review
- (-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice.Neurobiology of disease · 2019Article
- Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis.Neurobiology of disease · 2019Article
- Stem cell therapy for neurological disorders: A focus on aging.Neurobiology of disease · 2019Review
- Age-Induced Spatial Memory Deficits in Rats Are Correlated with Specific Brain Region Alterations in Microglial Morphology and Gene Expression.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Article
- Astaxanthin supplementation modulates cognitive function and synaptic plasticity in young and aged mice.GeroScience · 2019Article
- Preface: Setting the stage for understanding alcohol effects in late aging: A special issue including both human and rodent studies.International review of neurobiology · 2019Article
- RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer's Disease and Parkinson's Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia.Frontiers in neuroscience · 2019Article
- Antioxidant effects of compound walnut oil capsule in mice aging model induced by D-galactose.Food & nutrition research · 2018Article
- Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system.Oncotarget · 2017Review
- Old Maids: Aging and Its Impact on Microglia Function.International journal of molecular sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Aging is the primary risk factor for many neurodegenerative diseases. Thus, understanding the basic biological changes that take place with aging that lead to the brain being less resilient to disease progression of neurodegenerative diseases such as Parkinson's disease or Alzheimer's disease or insults to the brain such as stroke or traumatic brain injuries. Clearly this will not cure the disease per se, yet increasing the ability of the brain to respond to injury could improve long term outcomes. The focus of this review is examining changes in microglia with age and possible therapeutic interventions involving the use of polyphenol rich dietary supplements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.