Evidence map›Paper›PMID 28162969›Full record

ArticleCell metabolism2017

Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.

Yi Fan, Jun-Ichi Hanai, Phuong T Le, Ruiye Bi, David Maridas, Victoria DeMambro, Carolina A Figueroa, Serkan Kir, Xuedong Zhou, Michael Mannstadt and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 262 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
262citing papers in PubMed, 3 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

262 citing papers in PubMed, 3 syntheses or guidelines pooled it, 381 citations in OpenAlex.

  1. [Recent Advances in the Interorgan Regulatory Roles of Adipose Tissue].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Pooled it
  2. Consequences of Aging on Bone.Aging and disease · 2023
    Pooled it
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202 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 2 countries.

Yi FanDivision of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, MA 02115, USA; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Jun-Ichi HanaiDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Phuong T LeMaine Medical Center Research Institute, Scarborough, ME 04074, USA.
Ruiye BiState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
David MaridasMaine Medical Center Research Institute, Scarborough, ME 04074, USA.
Victoria DeMambroMaine Medical Center Research Institute, Scarborough, ME 04074, USA.
Carolina A FigueroaMaine Medical Center Research Institute, Scarborough, ME 04074, USA.
Serkan KirDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
Xuedong ZhouState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Michael MannstadtEndocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
Roland BaronDivision of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, MA 02115, USA; Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
Roderick T BronsonDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02215, USA.
Mark C HorowitzDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT 06510, USA.
Joy Y WuDivision of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA.
John P BilezikianDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
David W DempsterDepartment of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Clifford J RosenMaine Medical Center Research Institute, Scarborough, ME 04074, USA. Electronic address: rosenc@mmc.org.
Beate LanskeDivision of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, MA 02115, USA; Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA. Electronic address: beate_lanske@hsdm.harvard.edu.
Harvard University · USMaine Medical Center Research Institute · USMassachusetts General Hospital · USColumbia University · USMaine Medical Center · USBeth Israel Deaconess Medical Center · USSichuan University · CNStanford University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0M
Progenitor Cell Analysis CoreP30GM106391 · NIGMS · MAINEHEALTH · PI ROSEN, CLIFFORD JAMES · 2013 to 2017
$5.7M
The Regulation of the Parathyroid GlandR01DK097105 · NIDDK · HARVARD MEDICAL SCHOOL · PI MANNSTADT, BEATE · 2012 to 2015
$2.2M
Mode of Action of GCM2, the Essential Parathyroid Transcription FactorR01DK100584 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNSTADT, MICHAEL · 2014 to 2018
$1.8M
Osteoblastic Respiration and IRS SignalingR21AR066120 · NIAMS · MAINEHEALTH · PI ROSEN, CLIFFORD JAMES · 2015 to 2016
$411k
Roles of tumor-derived PTHrP in skeletal muscle atrophy and cancer cachexiaK99CA197410 · NCI · DANA-FARBER CANCER INST · PI KIR, SERKAN · 2016 to 2017
$245k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K99 CA197410NIAMS NIH HHS R21 AR066120NIDDK NIH HHS R01 DK097105NIDDK NIH HHS R01 DK100584NIDDK NIH HHS R24 DK092759NIGMS NIH HHS P30 GM106391
6 · The paper itself

Abstract

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in mesenchymal stem cells using Prx1Cre and found low bone formation, increased bone resorption, and high bone marrow adipose tissue (BMAT). Bone marrow adipocytes traced to Prx1 and expressed classic adipogenic markers and high receptor activator of nuclear factor kappa B ligand (Rankl) expression. RANKL levels were also elevated in bone marrow supernatant and serum, but undetectable in other adipose depots. By cell sorting, Pref1

Indexed as

AdipocytesAdipogenesisAdipose TissueAnimalsBiomarkersBone and BonesBone Marrow CellsCell CountCell LineageHumansIntegrasesMaleMesenchymal Stem CellsMiceOsteoblastsOsteoporosisBiomarkersCre recombinaseIntegrasesParathyroid HormoneRANK LigandReceptor, Parathyroid Hormone, Type 1bone resorptionlineagePTHRANKLreceptor

Identifiers

PMID28162969
PMCPMC5342925
OpenAlexW2585649126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.