SynthesisJournal of shoulder and elbow surgery2017
Genetic and familial predisposition to rotator cuff disease: a systematic review.
Synthesis in Journal of shoulder and elbow surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06379997 (Efficacy of Oral Hyaluronic Acid and Collagen Supplementation Compared With Hyaluronic Acid Infiltration Treatment in Rotator Cuff Tendinopathies), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Oral Hyaluronic Acid and Collagen Supplementation Compared With Hyaluronic Acid Infiltration Treatment in Rotator Cuff Tendinopathies: A Prospective Study
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Surgery for rotator cuff tears.The Cochrane database of systematic reviews · 2019Pooled it
- Genetic basis of rotator cuff injury: a systematic review.BMC medical genetics · 2019Pooled it
- Shoulder and genetics: what orthopedic surgeons need to know.JSES reviews, reports, and techniques · 2026Review
- Rotator cuff disease, repair and augmentation.Bulletin of the Hospital for Joint Disease (2013) · 2026Review
- The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair.Gels (Basel, Switzerland) · 2024Review
- Factors associated with genetic markers for rotator cuff disease in patients with atraumatic rotator cuff tears.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Advancements in the diagnosis and management of rotator cuff tears. The role of artificial intelligence.Journal of orthopaedics · 2024Review
- Abnormal Laboratory Values for Metabolic and Hormonal Syndromes Are Prevalent Among Patients Undergoing Rotator Cuff Repair.Arthroscopy, sports medicine, and rehabilitation · 2023Article
- Article
- A predictive model for the critical shoulder angle based on a three-dimensional analysis of scapular angular and linear morphometrics.BMC musculoskeletal disorders · 2022Observational
- Kinesio taping application for rotator cuff disease: Beneficial or harmful? - A Cochrane Review summary with commentary.Turkish journal of physical medicine and rehabilitation · 2022Article
- Risk factors for degenerative, symptomatic rotator cuff tears: a case-control study.Journal of shoulder and elbow surgery · 2022Article
- The role of familial predisposition in imaging-confirmed atraumatic rotator cuff tears.Journal of shoulder and elbow surgery · 2022Article
- Optimal Management of Partial Thickness Rotator Cuff Tears: Clinical Considerations and Practical Management.Orthopedic research and reviews · 2022Review
- Risk factors for full-thickness rotator cuff tears: a systematic review and meta-analysis.EFORT open reviews · 2021Review
- Personalized, Predictive, Participatory, Precision, and Preventive (P5) Medicine in Rotator Cuff Tears.Journal of personalized medicine · 2021Article
- [Rotator cuff tear : Indications and pathology-specific reconstructive procedures].Der Unfallchirurg · 2021Review
- Development and Validation of an Electronic Medical Record Algorithm to Identify Phenotypes of Rotator Cuff Tear.PM & R : the journal of injury, function, and rehabilitation · 2020Article
- Genetic Aspects in Shoulder Disorders.Revista brasileira de ortopedia · 2020Article
- Prediction of Rotator Cuff Injury Associated with Acromial Morphology: A Three-Dimensional Measurement Study.Orthopaedic surgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRotator cuff disease is a common disorder leading to shoulder pain and loss of function. Its etiology in atraumatic cases is uncertain and is likely to extend beyond repetitive microtrauma or overuse. Our objective was to determine whether there is a genetic or familial predisposition to rotator cuff disease.
methodsA literature search of PubMed and Embase databases identified 251 citations. After review of the titles, abstracts, and full articles, 7 met our inclusion and exclusion criteria.
resultsFour studies assessed familial predisposition to rotator cuff disease. One of these demonstrated that siblings of an individual with a rotator cuff tear were more likely to develop a full-thickness tear and more likely to be symptomatic. A 5-year follow-up showed that the relative risks were increased for the siblings to have a full-thickness tear, for a tear to progress in size, and for being symptomatic. Another study demonstrated that a significantly higher number of individuals with tears had family members with a history of tears or surgery than those without tears did. The other 3 studies investigated whether a genetic predisposition to rotator cuff disease exists and found significant association of haplotypes in DEFB1, FGFR1, FGF3, ESRRB, and FGF10 and 2 single-nucleotide polymorphisms within SAP30BP and SASH1.
conclusionPrior studies provide preliminary evidence for genetic and familial predisposition to rotator cuff disease. However, there is a lack of large genome-wide studies that can provide more definitive information and guide early detection of individuals at risk, prophylactic rehabilitation, and potential gene therapies and regenerative medicine interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.