Evidence map›Paper›PMID 28162809›Full record

ArticleNeuron2017

Axonal Endoplasmic Reticulum Ca

Jaime de Juan-Sanz, Graham T Holt, Eric R Schreiter, Fernando de Juan, Douglas S Kim, Timothy A Ryan

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 283 citations in OpenAlex.

  1. Article
  2. Article
  3. Asymmetric distribution of mitochondrial CaExperimental & molecular medicine · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Mitochondrial CaNature metabolism · 2026
    Article
  13. Review
  14. Visual input drives diverse ER calcium signals in neuronsbioRxiv : the preprint server for biology · 2025
    Article
  15. Activation of CaExperimental brain research · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Deep mapping of thebioRxiv : the preprint server for biology · 2025
    Article
  20. Resting CaCellular and molecular life sciences : CMLS · 2025
    Article

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Jaime de Juan-SanzDepartment of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA.
Graham T HoltJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Eric R SchreiterJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Fernando de JuanDepartment of Physics, University of Oxford, Oxford, OX1 3NP, UK.
Douglas S KimJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Timothy A RyanDepartment of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: taryan@med.cornell.edu.
Janelia Research Campus · USCornell University · USHoward Hughes Medical Institute · USUniversity of Oxford · GBWeill Cornell Medicine · US

Funding

Physiology of Single Synaptic CNS TerminalsR01NS036942 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Timothy Aidan Ryan · 1998 to 2026
$6.8M
Quantitative Mapping of Molecules and Release Properties at Nerve TerminalsR01MH085783 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI RYAN, TIMOTHY AIDAN · 2010 to 2019
$4.4M
Physiology of Single Synaptic CNS TerminalsR37NS036942 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI RYAN, TIMOTHY AIDAN · 2016 to 2022
$3.5M
NIMH NIH HHS R01 MH085783NINDS NIH HHS R01 NS036942NINDS NIH HHS R37 NS036942
6 · The paper itself

Abstract

Although the endoplasmic reticulum (ER) extends throughout axons and axonal ER dysfunction is implicated in numerous neurological diseases, its role at nerve terminals is poorly understood. We developed novel genetically encoded ER-targeted low-affinity Ca

Indexed as

AnimalsAxonsCalciumCalcium ChannelsCell MembraneCentral Nervous SystemEndoplasmic ReticulumPresynaptic TerminalsRats, Sprague-DawleySynaptic TransmissionCalciumCalcium ChannelsCa(2+) imagingER-GCaMPGCaMP6low affinity Ca(2+) indicatorpresynaptic endoplasmic reticulumSTIM1

Identifiers

PMID28162809
PMCPMC5325711
OpenAlexW2584451192

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.