ArticleCortex; a journal devoted to the study of the nervous system and behavior2017
Neural mechanisms of mood-induced modulation of reality monitoring in schizophrenia.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- A randomised controlled trial investigating the causal role of the medial prefrontal cortex in mediating self-agency during speech monitoring and reality monitoring.Scientific reports · 2024Trial
- Impaired Speaking-Induced Suppression Predicts Degraded Agency and Hallucination Severity in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Reduced neural connectivity in the caudate anterior head predicts hallucination severity in schizophrenia.Schizophrenia research · 2023Article
- Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: aTranslational psychiatry · 2022Article
- Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States-A Systematic Review of fMRI Studies.Journal of clinical medicine · 2021Review
- Multivariate pattern analysis of brain structure predicts functional outcome after auditory-based cognitive training interventions.NPJ schizophrenia · 2021Article
- Is internal source memory recognition modulated by emotional encoding contexts?Psychological research · 2021Article
- The Role of the Medial Prefontal Cortex in Self-Agency in Schizophrenia.Journal of psychiatry and brain science · 2021Article
- A decrease in spontaneous activity in medial prefrontal cortex is associated with sustained hallucinations in chronic schizophrenia: An NIRS study.Scientific reports · 2020Article
- Establishing a Causal Role for Medial Prefrontal Cortex in Reality Monitoring.Frontiers in human neuroscience · 2020Article
- Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Reality monitoring is the ability to accurately distinguish the source of self-generated information from externally-presented information. Although people with schizophrenia (SZ) show impaired reality monitoring, nothing is known about how mood state influences this higher-order cognitive process. Accordingly, we induced positive, neutral and negative mood states to test how different mood states modulate subsequent reality monitoring performance. Our findings indicate that mood affected reality monitoring performance in HC and SZ participants in both similar and dissociable ways. Only a positive mood facilitated task performance in Healthy Control (HC) subjects, whereas a negative mood facilitated task performance in SZ subjects. Yet, when both HC and SZ participants were in a positive mood, they recruited medial prefrontal cortex (mPFC) to bias better subsequent self-generated item identification, despite the fact that mPFC signal was reduced in SZ participants. Additionally, in SZ subjects, negative mood states also modulated left and right dorsal mPFC signal to bias better externally-presented item identification. Together our findings reveal that although the mPFC is hypoactive in SZ participants, mPFC signal plays a functional role in mood-cognition interactions during both positive and negative mood states to facilitate subsequent reality monitoring decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.