Evidence map›Paper›PMID 28162137›Full record

ArticleJournal of the International Neuropsychological Society : JINS2017

Are Parkinson's Patients More Vulnerable to the Effects of Cardiovascular Risk: A Neuroimaging and Neuropsychological Study.

Jacob D Jones, Jared J Tanner, Michael Okun, Catherine C Price, Dawn Bowers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Anticholinergic Medication Burden and Cognitive Subtypes in Parkinson's Disease without Dementia.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jacob D Jones1Department of Clinical and Health Psychology,McKnight Brain Institute,University of Florida,Gainesville,Florida.
Jared J Tanner1Department of Clinical and Health Psychology,McKnight Brain Institute,University of Florida,Gainesville,Florida.
Michael Okun2Center for Movement Disorders and Neurorestoration,McKnight Brain Institute,University of Florida,Gainesville,Florida.
Catherine C Price1Department of Clinical and Health Psychology,McKnight Brain Institute,University of Florida,Gainesville,Florida.
Dawn Bowers1Department of Clinical and Health Psychology,McKnight Brain Institute,University of Florida,Gainesville,Florida.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
White Matter Connectivity and PD Cognitive PhenotypesR01NS082386 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2013 to 2017
$2.3M
White Matter and Cognition in Parkinson's DiseaseK23NS060660 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2007 to 2011
$619k
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NIA NIH HHS P30 AG028740NINDS NIH HHS K23 NS060660NINDS NIH HHS R01 NS082386
6 · The paper itself

Abstract

objectivesThis study examined whether individuals with Parkinson's disease (PD) are at increased vulnerability for vascular-related cognitive impairment relative to controls. The underlying assumption behind this hypothesis relates to brain reserve and that both PD and vascular risk factors impair similar fronto-executive cognitive systems.

methodsThe sample included 67 PD patients and 61 older controls (total N=128). Participants completed neuropsychological measures of executive functioning, processing speed, verbal delayed recall/memory, language, and auditory attention. Cardiovascular risk was assessed with the Framingham Cardiovascular Risk index. Participants underwent brain imaging (T1 and T2 FLAIR). Trained raters measured total and regional leukoaraiosis (periventricular, deep subcortical, and infracortical).

resultsHierarchical regressions revealed that more severe cardiovascular risk was related to worse executive functioning, processing speed, and delayed verbal recall in both Parkinson patients and controls. More severe cardiovascular risk was related to worse language functioning in the PD group, but not controls. In contrast, leukoaraiosis related to both cardiovascular risk and executive functioning for controls, but not the PD group.

conclusionsOverall, results revealed that PD and cardiovascular risk factors are independent risk factors for cognitive impairment. Generally, the influence of cardiovascular risk factors on cognition is similar in PD patients and controls. (JINS, 2017, 23, 322-331).

Indexed as

AgedAged, 80 and overCardiovascular DiseasesCognitive DysfunctionComorbidityFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsParkinson DiseaseRiskCerebrovascular diseasesCognitionExecutive functionMagnetic resonance imagingMemoryParkinson’s disease

Identifiers

PMID28162137
PMCPMC5729910

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.