ArticleInternational urology and nephrology2017
Autologous platelet-rich plasma (PRP) in chronic penile lichen sclerosus: the impact on tissue repair and patient quality of life.
Article in International urology and nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Injection Treatments for Vulvovaginal Atrophy of Menopause: A Systematic Review.Aesthetic plastic surgery · 2023Pooled it
- Efficacy of platelet-rich fibrin compared with triamcinolone acetonide as injective therapy in the treatment of symptomatic oral lichen planus: a pilot study.Clinical oral investigations · 2021Trial
- Lichen sclerosus. Part 2. Guideline of the DGG, DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No. 013-105, July 2025.Geburtshilfe und Frauenheilkunde · 2026Article
- Platelet-rich therapies in cutaneous and mucocutaneous disorders characterized by inflammatory tissue responses: mechanistic insights and clinical evidence.Frontiers in medicine · 2026Review
- Treatments in oral lichen planus: a review.Frontiers in oral health · 2026Review
- Article
- The impact of genital lichen sclerosus in men and women on quality of life: a prospective cohort study.International journal of women's dermatology · 2024Article
- Phimosis in Adults: Narrative Review of the New Available Devices and the Standard Treatments.Clinics and practice · 2024Review
- Review
- Platelet-Rich Plasma (PRP) in Dermatology: Cellular and Molecular Mechanisms of Action.Biomedicines · 2023Review
- Platelet-Rich Plasma (PRP) and Adipose-Derived Stem Cell (ADSC) Therapy in the Treatment of Genital Lichen Sclerosus: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Autologous lipoaspirate as a new treatment of vulvar lichen sclerosus: A review on literature.Experimental dermatology · 2022Review
- Platelet-Rich Plasma: A Comprehensive Review of Emerging Applications in Medical and Aesthetic Dermatology.The Journal of clinical and aesthetic dermatology · 2021Review
- Successful Treatment of Corticosteroid-Induced Rosacea-Like Dermatitis with Platelet-Rich Plasma Mesotherapy: Report of Seven Cases.Dermatology and therapy · 2021Article
- Platelet-rich plasma for the treatment of lichen sclerosus.Plastic and aesthetic research · 2021Article
- Surgical management and outcomes of adult acquired buried penis with and without lichen sclerosus: a comparative analysis.International urology and nephrology · 2020Article
- Platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus in a premenopausal woman: A case report.Case reports in women's health · 2018Article
- [Lichen sclerosus : Symptoms, diagnosis, therapeutic procedures].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLichen sclerosus (LS) is a chronic inflammatory skin condition that frequently involves the anogenital region. Ongoing research is focused on finding more effective treatments for tissue repair and reducing symptoms. The aim of this study is to evaluate the effectiveness of platelet-rich plasma (PRP) local injections in penile LS.
methodsForty-five male patients affected by penile LS underwent injections of autologous PRP in the affected skin areas. Age at diagnosis and at first treatment, number of treatments, clinical conditions (phimosis, splitting, inflammation, synechiae, meatus stenosis), symptoms (pain, burning, itching), and functional impairment were considered. Treatment efficacy was also evaluated through the Investigator's Global Assessment (IGA) on a six-point Likert scale and the Dermatology Life Quality Index (DLQI).
resultsThe patient age at LS diagnosis was 36.20 ± 9.19 years, while the mean age at the first PRP treatment was 42.96 ± 11.32 years (p < 0.001). The number of treatments/patient ranged from 2 to 10. The follow-up was 17.60 ± 5.63 months. After PRP injections, it was observed in all patients a significant improvement in clinical conditions, with reduction/disappearance of symptoms. Topical steroid therapy, interrupted before PRP treatment, was not restarted by any patient. Only one patient underwent a later circumcision procedure. Both IGA scale and DLQI score showed a significant difference (p < 0.001) before and after PRP treatment.
conclusionsPRP treatment in penile LS seems to be helpful to regenerate scarring, reduce symptoms, and improve patient quality of life. Further studies are necessary to evaluate long-term results.
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