ArticleMedical oncology (Northwood, London, England)2017
Concurrent chemotherapy alone versus irreversible electroporation followed by chemotherapy on survival in patients with locally advanced pancreatic cancer.
Article in Medical oncology (Northwood, London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Irreversible Electroporation in Patients with Pancreatic Cancer: How Important Is the New Weapon?BioMed research international · 2018Pooled it
- High-voltage electrical pulses for pancreatic cancer treatment in the era of precision medicine.International journal of surgery (London, England) · 2026Review
- Radiomics Beyond Radiology: Literature Review on Prediction of Future Liver Remnant Volume and Function Before Hepatic Surgery.Journal of clinical medicine · 2025Review
- Consensus Guidelines of Irreversible Electroporation for Pancreatic Tumors: Protocol Standardization Using the Modified Delphi Technique.Seminars in interventional radiology · 2024Review
- Chemotherapy-induced bowel ischemia: diagnostic imaging overview.Abdominal radiology (New York) · 2022Review
- Dynamic contrast-enhanced (DCE) imaging: state of the art and applications in whole-body imaging.Japanese journal of radiology · 2022Review
- Benefitial role of electrochemotherapy in locally advanced pancreatic cancer - radiological perspective.Polish journal of radiology · 2022Review
- Basics in Magnetic Resonance guided Focused Ultrasound: technical basis and clinical application. A brief overview.Acta bio-medica : Atenei Parmensis · 2021Review
- The role of interventional radiology in hepatic and renal hemorrhage embolization: single center experience and literature review.Acta bio-medica : Atenei Parmensis · 2021Review
- When to perform vertebroplasty? A retrospective analysis from a single center and a review of the literature.Acta bio-medica : Atenei Parmensis · 2021Review
- Article
- Review
- Locally Advanced Pancreatic Cancer: Percutaneous Management Using Ablation, Brachytherapy, Intra-arterial Chemotherapy, and Intra-tumoral Immunotherapy.Current oncology reports · 2021Review
- Optimizing Patient Selection for Irreversible Electroporation of Locally Advanced Pancreatic Cancer: Analyses of Survival.Frontiers in oncology · 2021Article
- Review
- The role of imaging in surgical planning for liver resection: what the radiologist need to know.Acta bio-medica : Atenei Parmensis · 2020Article
- Imaging guided percutaneous renal biopsy: do it or not?Acta bio-medica : Atenei Parmensis · 2020Article
- Basic embolization techniques: tips and tricks.Acta bio-medica : Atenei Parmensis · 2020Review
- The texture analysis as a predictive method in the assessment of the cytological specimen of CT-guided FNAC of the lung cancer.Medical oncology (Northwood, London, England) · 2020Article
- Preliminary results in unresectable cholangiocarcinoma treated by CT percutaneous irreversible electroporation: feasibility, safety and efficacy.Medical oncology (Northwood, London, England) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic adenocarcinoma is one of the most fatal cancers, characterized by aggressive tumor growth and a short patient survival time between diagnosis and death. Safe and effective treatment options are limited, especially in cases when surgical resection is not possible. Irreversible electroporation (IRE) is a non-thermal ablation technique recently introduced in the treatment of pancreatic cancer. From 2013 to 2016, 29 cases of locally advanced pancreatic cancer (LAPC) treated with IRE were retrospectively analyzed and the median overall survival (OS) rates were compared with patients with the same diagnosis who received standard chemotherapy as reported in the literature. Literature was selected according to a predetermined protocol. Secondarily, preoperative and postoperative Karnofsky scores of the 29 IRE-treated patients were compared to determine improvement in quality-of-life. Median OS of IRE-treated patients was 14 months (SE 11 months, 95% CI range 9.86-18.14). For IRE-treated patients, the Karnofsky score increased from Tzero to T3m by a mean of 28.28 (SE 2.11, 95% CI range 23.95-32.60). In 27 patients, 6-month imaging follow-up showed a mean lesion volumetric decrease percentage of 40.32% (SE 2.76, 95% CI 34.63-46.01%). Treatment with IRE followed by chemotherapy substantially increases median OS rate and quality-of-life of LAPC-diagnosed patients when compared to patients treated with traditional methods, including chemotherapy. Further investigation of this multi-modal treatment is warranted.
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