Evidence map›Paper›PMID 28161822›Full record

SynthesisEuropean journal of pediatrics2017

Blistering eruptions in childhood Henoch-Schönlein syndrome: systematic review of the literature.

Vera Ramelli, Sebastiano A G Lava, Giacomo D Simonetti, Mario G Bianchetti, Gian Paolo Ramelli, Gregorio P Milani

Open access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Dapsone in immunoglobulin A-associated vasculitis.European journal of pediatrics · 2019
    Article
  9. Sex Differences in Pediatric Rheumatology.Clinical reviews in allergy & immunology · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Vera RamelliPediatric Department of Southern Switzerland, 6500, Bellinzona, Switzerland.
Sebastiano A G LavaUniversity Children's Hospital Bern and University of Bern, Bern, Switzerland.
Giacomo D SimonettiPediatric Department of Southern Switzerland, 6500, Bellinzona, Switzerland.
Mario G BianchettiPediatric Department of Southern Switzerland, 6500, Bellinzona, Switzerland. mario.bianchetti@usi.ch.
Gian Paolo RamelliPediatric Department of Southern Switzerland, 6500, Bellinzona, Switzerland.
Gregorio P MilaniPediatric unit, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
University Children’s Hospital Bern · CHUniversity of Bern · CHUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The occurrence of blistering eruptions in childhood Henoch-Schönlein syndrome has been so far addressed exclusively in individual case reports. To describe epidemiology, clinical presentation, and therapeutic options in Henoch-Schönlein patients ≤18 years of age with blistering eruptions, we completed a systematic literature search. For the final analysis, we retained 39 reports. Ten children with blisters were found in 7 (1.5%) case series containing a total of 666 unselected pediatric Henoch-Schönlein cases. We also found 41 individually documented cases of Henoch-Schönlein syndrome with blistering eruptions. Blistering eruptions and purpura were distributed very similarly, blisters developed concomitantly with palpable purpura or with a latency of ≤14 days, and 80% of the cases remitted within 4 weeks with a similar course in children managed expectantly and in those managed with steroids.

conclusionBlistering eruptions are rare in Henoch-Schönlein syndrome. They can be a source of diagnostic dilemma but do not have any prognostic value since they almost always spontaneously subside within 4 weeks. What is known: • Textbooks and reviews marginally refer to the occurrence of blistering eruptions in children with Henoch-Schönlein syndrome. What is new • Blistering eruptions occur in <2% of cases. • Blisters and purpura are distributed similarly, blisters develop concomitantly with purpura or with a latency of ≤14 days. • Almost all cases remit within 4 weeks with a similar course in children managed expectantly and in those managed with systemic steroids.

Indexed as

BlisterChildFemaleHumansIgA VasculitisMaleSkin Diseases, VascularSteroidsSteroidsBlisterColchicineGlucocorticoidsPurpuraSchönlein-HenochVasculitis

Identifiers

PMID28161822
OpenAlexW2584799690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.