ArticlePsychopharmacology2017
Do alcohol-dependent patients show different neural activation during response inhibition than healthy controls in an alcohol-related fMRI go/no-go-task?
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The effect of task complexity on the neural network for response inhibition: An ALE meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct.Psychopharmacology · 2024Pooled it
- Neural correlates of impulsivity in bipolar disorder: A systematic review and clinical implications.Neuroscience and biobehavioral reviews · 2023Pooled it
- Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics.Neuroscience and biobehavioral reviews · 2021Pooled it
- Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review.Neuron · 2018Pooled it
- Functional and clinical outcomes of FMRI-based neurofeedback training in patients with alcohol dependence: a pilot study.European archives of psychiatry and clinical neuroscience · 2022Trial
- An event-related potential (ERP) study of the transfer of response inhibition training to interference control.Experimental brain research · 2021Trial
- An experimental examination of cognitive processes and response inhibition in patients seeking treatment for buying-shopping disorder.PloS one · 2019Trial
- Dysregulation of inhibitory control in young adult binge drinkers: Neuroimaging evidence of gender differences associated with misusing alcohol to cope with negative affect.Addiction neuroscience · 2025Article
- Altered prefrontal signaling during inhibitory control in a salient drug context in cocaine use disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Neural Signature of Impaired Inhibitory Control in Individuals with Heroin Use Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Alcohol- and non-alcohol-related interference: An fMRI study of treatment-seeking adults with alcohol use disorder.Drug and alcohol dependence · 2022Article
- Statistical Nonparametric fMRI Maps in the Analysis of Response Inhibition in Abstinent Individuals with History of Alcohol Use Disorder.Behavioral sciences (Basel, Switzerland) · 2022Article
- Temporally dynamic neural correlates of drug cue reactivity, response inhibition, and methamphetamine-related response inhibition in people with methamphetamine use disorder.Scientific reports · 2022Article
- Right Inferior Frontal Activation During Alcohol-Specific Inhibition Increases With Craving and Predicts Drinking Outcome in Alcohol Use Disorder.Frontiers in psychiatry · 2022Article
- The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Neural mechanisms of sexual decision-making in women with alcohol use disorder.Psychopharmacology · 2021Article
- An integrated multimodal model of alcohol use disorder generated by data-driven causal discovery analysis.Communications biology · 2021Article
- Stop What You're Doing!-An fMRI Study on Comparisons of Neural Subprocesses of Response Inhibition in ADHD and Alcohol Use Disorder.Frontiers in psychiatry · 2021Article
- Brain Network Underlying Executive Functions in Gambling and Alcohol Use Disorders: An Activation Likelihood Estimation Meta-Analysis of fMRI Studies.Brain sciences · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAlcohol dependence is associated with impaired response inhibition and heightened cue reactivity towards alcohol-related stimuli. Several brain areas, but mainly prefrontal structures, have been linked to response inhibition in addiction. This study aimed at combining both aspects: salience of drug-associated cues and response inhibition using a go/no-go task with alcohol-associated stimuli during functional magnetic resonance imaging (fMRI).
objectivesNineteen abstinent alcohol-dependent patients (ADP) and 21 healthy control subjects (HC) were compared on blood oxygen level-dependent (BOLD) responses during successful inhibition of no-go stimuli and successful reactions to go stimuli.
resultsADP and HC did not significantly differ in their behavioural performance in the task. However, both groups performed worse during the inhibition of alcoholic-associated stimuli compared to neutral stimuli. On the neural level, ADP displayed enhanced BOLD activity relative to HC during successful response inhibition in several areas involved in visual processing, cognitive and impulse control, including occipital structures, anterior cingulate gyrus, medial frontal gyrus and medial orbitofrontal cortex.
conclusionsWe interpret these findings as a possible compensation strategy for impaired cognitive processing. Furthermore, the results underline the impact of salience of alcohol-related stimuli on response inhibition, which seems to affect both ADP and HC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.