Evidence map›Paper›PMID 28161530›Full record

Trial reportThe Journal of steroid biochemistry and molecular biology2017

Effects of cholecalciferol supplementation on serum and urinary vitamin D metabolites and binding protein in HIV-infected youth.

Allison Ross Eckard, Myrtle Thierry-Palmer, Natalia Silvestrov, Julia C Rosebush, Mary Ann O'Riordan, Julie E Daniels, Monika Uribe-Leitz, Danielle Labbato, Joshua H Ruff, Ravinder J Singh and 2 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of steroid biochemistry and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Allison Ross EckardMedical University of South Carolina, Charleston, SC, United States; Emory University School of Medicine, Atlanta, GA, United States. Electronic address: eckarda@musc.edu.
Myrtle Thierry-PalmerMorehouse School of Medicine, Atlanta, GA, United States.
Natalia SilvestrovMorehouse School of Medicine, Atlanta, GA, United States.
Julia C RosebushEmory University School of Medicine, Atlanta, GA, United States.
Mary Ann O'RiordanCase Western Reserve University Cleveland, OH, United States.
Julie E DanielsEmory University School of Medicine, Atlanta, GA, United States.
Monika Uribe-LeitzEmory University School of Medicine, Atlanta, GA, United States.
Danielle LabbatoCase Western Reserve University Cleveland, OH, United States.
Joshua H RuffEmory University School of Medicine, Atlanta, GA, United States.
Ravinder J SinghMayo Clinic, Rochester, MN, United States.
Vin TangprichaEmory University School of Medicine, Atlanta, GA, United States.
Grace A McComseyCase Western Reserve University Cleveland, OH, United States.
Emory University · USCase Western Reserve University · USMorehouse School of Medicine · USMayo Clinic in Arizona · USMedical University of South Carolina · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0M
TRANSPLANTATION OF EXOSOMES FROM HYPOXIA-PRECONDITIONED ADIPOSE-DERIVED STEM CELLS PROMOTES ANGIOGENESIS IN ISCHEMIC HEARTG12MD007602 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI BOND, VINCENT C · 2012 to 2017
$18.4M
Vitamin D, drug metabolism, and cardiovascular complications in pediatric HIVR01HD070490 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2011 to 2015
$1.7M
Vitamin D status and HIV-related complications in children and young adultsK23HD069199 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ECKARD, ALLISON ROSS · 2012 to 2016
$631k
NCATS NIH HHS UL1 TR000439NIAID NIH HHS P30 AI036219NIAID NIH HHS P30 AI050409NICHD NIH HHS K23 HD069199NICHD NIH HHS R01 HD070490NIMHD NIH HHS G12 MD007602
6 · The paper itself

Abstract

Vitamin D insufficiency is widespread in HIV-infected patients. HIV and/or antiretroviral therapy (ART), particularly efavirenz (EFV), may interfere with vitamin D metabolism. However, few data from randomized, controlled trials exist. Here, we investigate changes in vitamin D metabolites and binding protein (VDBP) after 6 months of supplementation in a randomized, active-control, double-blind trial investigating 2 different monthly cholecalciferol (vitamin D

Indexed as

AdolescentAdultAlkynesBenzoxazinesCholecalciferolCyclopropanesDietary SupplementsDouble-Blind MethodFemaleHIV InfectionsHumansMaleProtein BindingVitamin DVitamin D-Binding ProteinVitamin D Deficiency25-hydroxyvitamin DAlkynesBenzoxazinesCholecalciferolCyclopropanesefavirenzVitamin DVitamin D-Binding ProteinCholecalciferol supplementationHIVPediatrics and adolescentsRandomized-controlled trialVitamin DVitamin d binding proteinVitamin d metabolites

Identifiers

PMID28161530
PMCPMC5385603
OpenAlexW2585503942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.