Evidence map›Paper›PMID 28161520›Full record

ArticleBiochimica et biophysica acta. Molecular cell research2017

Expression profiling of colorectal cancer cells reveals inhibition of DNA replication licensing by extracellular calcium.

Abhishek Aggarwal, Herbert Schulz, Teresa Manhardt, Martin Bilban, Rajesh V Thakker, Enikö Kallay

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular cell research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Abhishek AggarwalDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, Austria.
Herbert SchulzCologne Center for Genomics (CCG), Cologne, Germany.
Teresa ManhardtDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, Austria.
Martin BilbanDepartment of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Austria.
Rajesh V ThakkerRadcliffe Department of Medicine, University of Oxford, UK.
Enikö KallayDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, Austria; Radcliffe Department of Medicine, University of Oxford, UK. Electronic address: enikoe.kallay@meduniwien.ac.at.
Medical University of Vienna · ATUniversity of Oxford · GB

Funding

Medical Research Council G1000467Medical Research Council G9825289Wellcome Trust
6 · The paper itself

Abstract

Colorectal cancer is one of the most common cancers in industrialised societies. Epidemiological studies, animal experiments, and randomized clinical trials have shown that dietary factors can influence all stages of colorectal carcinogenesis, from initiation through promotion to progression. Calcium is one of the factors with a chemoprophylactic effect in colorectal cancer. The aim of this study was to understand the molecular mechanisms of the anti-tumorigenic effects of extracellular calcium ([Ca

Indexed as

DNA ReplicationGene Expression ProfilingCaco-2 CellsCalciumColorectal NeoplasmsHT29 CellsHumansRNA, MessengerCalciumRNA, MessengerCalciumCalcium-sensing receptorColorectal cancerDNA replication licensingMinichromosome maintenance complex

Identifiers

PMID28161520
PMCPMC5424886
OpenAlexW2585029826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.