ReviewHeart rhythm2017
The burden of proof: The current state of atrial fibrillation prevention and treatment trials.
Review in Heart rhythm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- The association between hematological inflammatory markers and atrial fibrillation recurrence after radiofrequency ablation.Frontiers in medicine · 2026Article
- Article
- Elevated Lipoprotein(a) Levels and Atrial Fibrillation: A Systematic Review.Journal of lipid and atherosclerosis · 2023Article
- Association of lipid composition and unsaturated fatty acids of VLDL with atrial remodeling in metabolic syndrome.Scientific reports · 2023Article
- Race Correction and Algorithmic Bias in Atrial Fibrillation Wearable Technologies.Health equity · 2023Article
- Comprehensive metabolomic characterization of atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- Association of chronic kidney disease with all-cause mortality in patients hospitalized for atrial fibrillation and impact of clinical and socioeconomic factors on this association.Frontiers in cardiovascular medicine · 2022Article
- QTc Interval is Associated with Atrial Fibrillation in Individuals with Metabolic Syndrome Phenotype.International journal of general medicine · 2022Article
- Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it.Cardiovascular research · 2021Review
- Integrated Care in Atrial Fibrillation: A Road Map to the Future.Circulation. Cardiovascular quality and outcomes · 2021Review
- Application of Insertable Cardiac Monitor in Establishing a Dog Model of Atrial Fibrillation by High-Frequency Right Atrial Pacing.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Safety and efficacy of catheter ablation in atrial fibrillation patients with left ventricular dysfunction.Clinical cardiology · 2020Article
- The Pathogenic Role of Very Low Density Lipoprotein on Atrial Remodeling in the Metabolic Syndrome.International journal of molecular sciences · 2020Review
- Value of cystatin C in predicting atrial fibrillation recurrence after radiofrequency catheter ablation.Journal of geriatric cardiology : JGC · 2018Article
- Inflammation and atrial fibrillation: A comprehensive review.Journal of arrhythmia · 2018Review
- Article
- The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study.Frontiers in physiology · 2018Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 11 institutions in 4 countries.
Funding
Abstract
Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from concept to reality, and recent studies suggest lifestyle modification may help prevent AF recurrence. Emerging developments in genetics, imaging, and informatics also present new opportunities for personalized care. However, considerable challenges remain. These include a paucity of studies examining AF prevention, modest efficacy of existing antiarrhythmic therapies, diverse ablation technologies and practice, and limited evidence to guide management of high-risk patients with multiple comorbidities. Studies examining the long-term effects of AF catheter ablation on morbidity and mortality outcomes are not yet completed. In many ways, further progress in the field is heavily contingent on the feasibility, capacity, and efficiency of clinical trials to incorporate the rapidly evolving knowledge base and to provide substantive evidence for novel AF therapeutic strategies. This review outlines the current state of AF prevention and treatment trials, including the foreseeable challenges, as discussed by a unique forum of clinical trialists, scientists, and regulatory representatives in a session endorsed by the Heart Rhythm Society at the 12th Global CardioVascular Clinical Trialists Forum in Washington, DC, December 3-5, 2015.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.