ArticleOsteoarthritis and cartilage2017
Magic angle effect plays a major role in both T1rho and T2 relaxation in articular cartilage.
Article in Osteoarthritis and cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 105 citations in OpenAlex.
- Diffusion Tensor Imaging of Knee Cartilage for Detection of Early Osteoarthritis and Prediction of Radiographic Progression.Journal of magnetic resonance imaging : JMRI · 2026Article
- Adiabatic Pulse Shape Influence on the Orientation Dependence of TMagnetic resonance in medicine · 2026Article
- Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026Review
- Exploratory analysis of the 2-year changes in knee cartilage thickness and transverse relaxation time (T2) in ACL-injured versus healthy participants.Osteoarthritis and cartilage open · 2026Article
- Ultrashort echo time bi-component analysis of tibiotalar articular cartilage after long-distance running.European radiology · 2026Article
- Effect of Slice Thickness Variations on Knee Cartilage Quantification Using Magnetic Resonance Image Compilation SequencCurrent medical imaging · 2026Article
- Two Approaches to Solid-State NMR of Mobile Molecules in Nanoporous Materials.Molecules (Basel, Switzerland) · 2025Review
- Assessment of White Matter Changes Using Quantitative T1ρ Mapping in an Open-Field Low-Intensity Blast Mouse Model of Mild Traumatic Brain Injury (mTBI).International journal of molecular sciences · 2025Article
- TJournal of magnetic resonance imaging : JMRI · 2025Article
- Feasibility of a UTE Stack-of-Spirals Sequence for Biexponential TNMR in biomedicine · 2025Article
- Non-invasive evaluation of Achilles tendon and its enthesis using ultrashort echo time adiabatic TEuropean journal of radiology · 2025Article
- Orientation-independent quantification of macromolecular proton fraction in tissues with suppression of residual dipolar coupling.NMR in biomedicine · 2025Article
- Achilles tendon assessment on quantitative MRI: Sources of variability and relationships to tendinopathy.Scandinavian journal of medicine & science in sports · 2024Article
- Fast dual-echo estimation of apparent long T2 fraction using ultrashort echo time magnetic resonance imaging in tibialis tendons and its osteoporosis-related differences in women.Quantitative imaging in medicine and surgery · 2024Article
- Whole knee joint mapping using a phase modulated UTE adiabatic TMagnetic resonance in medicine · 2024Article
- Variation in cartilage T2 and T2* mapping of the wrist: a comparison between 3- and 7-T MRI.European radiology experimental · 2023Article
- Assessment of ultrashort echo time (UTE) TQuantitative imaging in medicine and surgery · 2023Article
- Correlations between elastic modulus and ultrashort echo time (UTE) adiabatic T1ρ relaxation time (UTE-Adiab-T1ρ) in Achilles tendons and entheses.Journal of biomechanics · 2023Article
- The effect of cartilage dehydration and rehydration on quantitative ultrashort echo time biomarkers.Quantitative imaging in medicine and surgery · 2023Article
- Ultrashort echo time magnetization transfer imaging of knee cartilage and meniscus after long-distance running.European radiology · 2023Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeTo investigate the effect of sample orientation on T1rho and T2 values of articular cartilage in histologically confirmed normal and abnormal regions using a whole-body 3T scanner. MATERIALS AND
methodsEight human cadaveric patellae were evaluated using a 2D CPMG sequence for T2 measurement as well as a 2D spin-locking prepared spiral sequence and a 3D magnetization-prepared angle-modulated partitioned-k-space spoiled gradient echo snapshots (3D MAPSS) sequence for T1rho measurement. Each sample was imaged at six angles from 0° to 100° relative to the B
resultsOur study demonstrated a strong magic angle effect for T1rho and T2 relaxation in articular cartilage, especially in the deeper layers of cartilage. On average, T2 values were increased by 231.8% (72.2% for superficial, 237.6% for middle, and 187.9% for deep layers) while T1rho values were increased by 92% (31.7% for superficial, 69% for middle, and 140% for deep layers) near the magic angle. Both normal and abnormal cartilage showed similar T1rho and T2 magic angle effect.
conclusionsChanges in T1rho and T2 values due to the magic angle effect can be several times more than that caused by degeneration, and this may significantly complicate the clinical application of T1rho and T2 as an early surrogate marker for degeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.