ArticlePlacenta2017
Placental genetic variations in vitamin D metabolism and birthweight.
Article in Placenta, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- The role of vitamin D deficiency in fetal growth restriction: a systematic review.Frontiers in medicine · 2025Pooled it
- Exploring Gene-Diet Interactions for Mother-Child Health: A Systematic Review of Epidemiological Studies.Nutrients · 2024Pooled it
- Pooled it
- Vitamin D status and response to supplementation in very preterm infants: A prospective cohort study.European journal of clinical nutrition · 2026Observational
- A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Review
- Gestational vitamin D and offspring fracture risk: do associations persist into mid adolescence?European journal of clinical nutrition · 2024Article
- Associations between placental hydroxymethylation and birthweight.Epigenetics reports · 2024Article
- Impact of vitamin D on maternal and fetal health: A review.Food science & nutrition · 2022Review
- Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight.Journal of molecular medicine (Berlin, Germany) · 2022Article
- Associations of perinatal exposure to PMEnvironmental research · 2022Article
- Vitamin D receptor gene polymorphisms and haplotypes in the etiology of recurrent miscarriages.Scientific reports · 2021Article
- Article
- The role of vitamin D in perinatology. An up-to-date review.Archives of medical science : AMS · 2021Article
- A genetic approach to study the relationship between maternal Vitamin D status and newborn anthropometry measurements: the Vitamin D pregnant mother (VDPM) cohort study.Journal of diabetes and metabolic disorders · 2020Article
- New Insights into the Pathogenesis and Treatment of Malnutrition.Gastroenterology clinics of North America · 2018Review
- Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionVitamin D has pleiotropic functions that regulate fetal growth and development. We investigated associations of common placental genetic variations in vitamin D metabolism with birthweight.
methodsThe study was conducted among participants (506 maternal-infant pairs) of a pregnancy cohort study. Data were collected using interviewer-administered questionnaires and post-delivery medical record abstraction. DNA, extracted from placental samples collected at delivery, was genotyped for eight single nucleotide polymorphisms (SNPs) in five vitamin D metabolism genes (CUBN, LRP2, VDR, GC, and CYP2R1). Linear and logistic regression models were used to evaluate associations of SNPs with birthweight and risk of low birthweight, respectively. Effect modification of associations by infant sex was examined using stratified analyses and interaction terms in regression models.
resultsMean (standard-deviation) birthweight among all, male, and female infants was 3482.1 (549.9), 3544.6 (579.0) and 3419.2 (512.5) grams, respectively. Each copy of the minor allele of rs2282679 (GC) was associated with a 68.6 g (95%CI:3.1134.7 g) increase in birthweight overall. Sex-specific associations were observed for SNP rs4667591 (LRP2) (p-value for interaction < 0.001). Each copy of the minor allele of rs4667591 was associated with a 124.7 g (95%CI:20.1229.0 g) increase in birthweight among female infants, and a suggested 81.6 g decrease in birthweight among male infants (95%CI:-183.7,20.5 g). DISCUSSION: Our study identified overall and sex-specific associations between placental genetic variations in vitamin D metabolism and birthweight. If confirmed by larger replication studies, observed associations may provide insight into mechanistic underpinnings of the relationships between placental vitamin D metabolism and birth size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.