Evidence map›Paper›PMID 28161064›Full record

ArticlePlacenta2017

Dysregulation of maternal and placental vitamin D metabolism in preeclampsia.

J A Tamblyn, R Susarla, C Jenkinson, L E Jeffery, O Ohizua, R F Chun, S Y Chan, M D Kilby, M Hewison

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.

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  16. Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024
    Review
  17. Review
  18. Review
  19. Article
  20. The role of vitamin D in perinatology. An up-to-date review.Archives of medical science : AMS · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

J A TamblynInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK; Fetal Medicine Centre, Birmingham Women's Foundation Trust, Edgbaston, Birmingham, B15 2TG, UK; Centre for Women's & Newborn Health, Birmingham Health Partners, Birmingham, B15 2TH, UK.
R SusarlaInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK.
C JenkinsonInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK.
L E JefferyInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK.
O OhizuaWomen, Children and Sexual Health Directorate, Walsall Hospitals NHS Trust, Walsall, WS2 9PS, UK.
R F ChunDepartment of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.
S Y ChanInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK; Department of Obstetrics and Gynecology, National University of Singapore, 119228, Singapore.
M D KilbyInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK; Fetal Medicine Centre, Birmingham Women's Foundation Trust, Edgbaston, Birmingham, B15 2TG, UK; Centre for Women's & Newborn Health, Birmingham Health Partners, Birmingham, B15 2TH, UK; Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, B15 2TH, UK.
M HewisonInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK; Centre for Women's & Newborn Health, Birmingham Health Partners, Birmingham, B15 2TH, UK; Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, B15 2TH, UK. Electronic address: m.hewison@bham.ac.uk.
University of Birmingham · GBBirmingham Women's Hospital · GBUniversity of California, Los Angeles · USWalsall Healthcare NHS Trust · GB

Funding

DBP and the bioavailability and function of vitamin DR01AR063910 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S, HEWISON, MARTIN · 2013 to 2017
$1.8M
NIAMS NIH HHS R01 AR063910
6 · The paper itself

Abstract

introductionEpidemiology has linked preeclampsia (PET) to decreased maternal serum 25-hydroxyvitamin D3 (25(OH)D3). However, alterations in systemic and placental/decidual transport and metabolism of 25(OH)D3 during pregnancy suggest that other forms of vitamin D may also contribute to the pathophysiology of PET.

methodsIn a cross sectional analysis of normal pregnant women at 1st (n = 25) and 3rd trimester (n = 21), pregnant women with PET (n = 22), and non-pregnant female controls (n = 20) vitamin D metabolites were quantified in paired maternal serum, placental, and decidual tissue.

resultsSerum 25(OH)D3 was not significantly different in sera across all four groups. In normal 3rd trimester pregnant women serum active 1,25-dihydroxyvitamin D3 (1,25(OH) DISCUSSION: These data indicate that PET is associated with decreased activation, increased catabolism, and impaired placental uptake of 25(OH)D3.

Indexed as

AdultBiological TransportCross-Sectional StudiesDeciduaFemaleHumansPlacentaPre-EclampsiaPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdVitamin DVitamin DDeciduaPlacentaPreeclampsiaPregnancyVitamin D

Identifiers

PMID28161064
PMCPMC5463036
OpenAlexW2566085762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.