ArticleIranian biomedical journal2017
Common Genetic Variant of insig2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
Article in Iranian biomedical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Integrative analysis of candidate MicroRNAs and gene targets for OSA management using in silico and in-vitro approach.Biotechnology notes (Amsterdam, Netherlands) · 2025Article
- A comprehensive review of genetic causes of obesity.World journal of pediatrics : WJP · 2024Review
- Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative Cross.Genes & nutrition · 2022Article
- Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity.International journal of molecular sciences · 2020Review
- Genetics of obesity and its measures in India.Journal of genetics · 2018Review
- INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program.Molecular medicine reports · 2018Article
- ESI Clinical Practice Guidelines for the Evaluation and Management of Obesity In India.Indian journal of endocrinology and metabolismArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
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Abstract
Background: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods: The variants were investigated for association in 642 obese and non-obese individuals. The genotyping of INSIG2 (rs7566605) single nucleotide polymorphism was analyzed by the TaqMan allelic discrimination protocol. Results: A significant association was observed for INSIG2 (rs7566605) single nucleotide polymorphism with obesity and obesity-related phenotypes. Furthermore, a significant relationship was found between the rs7566605 and insulin, homeostasis model of assessment-insulin resistance, the percentage of body fat, fat mass, leptin, and adiponectin. Conclusion: The present study observed significant association between INSIG2 (rs7566605) single nucleotide polymorphism and obesity, as well as obesity-associated phenotypes in North Indian population.
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