Evidence map›Paper›PMID 28160743›Full record

ArticleRedox biology2017

DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression.

Maceler Aldrovandi, Christine Hinz, Sarah N Lauder, Helen Podmore, Martin Hornshaw, David A Slatter, Victoria J Tyrrell, Stephen R Clark, Lawrence J Marnett, Peter W Collins and 2 more

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Neutrophils: As a Key Bridge between Inflammation and Thrombosis.Evidence-based complementary and alternative medicine : eCAM · 2022
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Phospholipid signaling in innate immune cells.The Journal of clinical investigation · 2018
    Review
  9. Review
  10. Article
  11. Article
  12. Oxidative lipidomics: applications in critical care.Current opinion in critical care · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Maceler AldrovandiSystems Immunity Research Institute, and Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Christine HinzSystems Immunity Research Institute, and Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Sarah N LauderSystems Immunity Research Institute, and Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Helen PodmoreThermoFisher Scientific, Stafford House, Boundary Way, Hemel Hempstead HP2 7GE, United Kingdom.
Martin HornshawThermoFisher Scientific, Stafford House, Boundary Way, Hemel Hempstead HP2 7GE, United Kingdom.
David A SlatterSystems Immunity Research Institute, and Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Victoria J TyrrellSystems Immunity Research Institute, and Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Stephen R ClarkSystems Immunity Research Institute, and Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Lawrence J MarnettVanderbilt Institute of Chemical Biology, Centre in Molecular Toxicology, Vanderbilt-Ingram Cancer Centre, Nashville, TN, USA.
Peter W CollinsSystems Immunity Research Institute, and Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Robert C MurphyDepartment of Pharmacology, University of Colorado Denver, Aurora, CO 80045, USA.
Valerie B O'DonnellSystems Immunity Research Institute, and Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address: o-donnellvb@cardifff.ac.uk.
Cardiff University · GBThermo Fisher Scientific (United Kingdom) · GBUniversity of Colorado Denver · USVanderbilt-Ingram Cancer Center

Funding

Pilot Study: POPULATION PHARMACOLOGYU54HL117798 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2016
$18.5M
British Heart Foundation RG/12/11/29815NHLBI NIH HHS U54 HL117798Wellcome Trust
6 · The paper itself

Abstract

Activated platelets generate an eicosanoid proposed to be 8-hydroxy-9,10-dioxolane A3 (DXA

Indexed as

Blood PlateletsCalciumCyclooxygenase 1DioxolanesEicosanoidsGene Expression RegulationHumansIntegrinsLipidsMacrophage-1 AntigenNeutrophilsOxidation-ReductionPhosphatidylethanolaminesPhospholipases A2, CytosolicPlatelet ActivationReceptor, PAR-1CalciumCyclooxygenase 1DioxolanesEicosanoidsformal glycolIntegrinsLipidsMacrophage-1 AntigenphosphatidylethanolaminePhosphatidylethanolaminesPhospholipases A2, Cytosolicprotease-activated receptor 4Receptor, PAR-1Receptors, ThrombinThrombinType C PhospholipasesCyclooxygenaseEicosanoidsMass spectrometryPhospholipidsPlatelets

Identifiers

PMID28160743
PMCPMC5288459
OpenAlexW2574592954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.