Evidence map›Paper›PMID 28160450›Full record

ArticlePediatric obesity2017

Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood.

L Chatzi, S L Rifas-Shiman, V Georgiou, K E Joung, S Koinaki, G Chalkiadaki, A Margioris, K Sarri, M Vassilaki, M Vafeiadi and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Pediatric obesity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 6 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 6 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

L ChatziDepartment of Social Medicine, University of Crete, Heraklion, Greece.
S L Rifas-ShimanObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
V GeorgiouDepartment of Social Medicine, University of Crete, Heraklion, Greece.
K E JoungDivision of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
S KoinakiDepartment of Social Medicine, University of Crete, Heraklion, Greece.
G ChalkiadakiDepartment of Social Medicine, University of Crete, Heraklion, Greece.
A MargiorisDepartment of Laboratory Medicine, University of Crete, Heraklion, Greece.
K SarriDepartment of Social Medicine, University of Crete, Heraklion, Greece.
M VassilakiDepartment of Social Medicine, University of Crete, Heraklion, Greece.
M VafeiadiDepartment of Social Medicine, University of Crete, Heraklion, Greece.
M KogevinasCentre for Research in Environmental Epidemiology, CREAL, Barcelona, Spain.
C MantzorosDivision of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
M W GillmanObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
E OkenObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
University of Crete · GRHarvard Pilgrim Health Care · USHarvard University · USCenter for Research in Environmental Epidemiology · ES

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
Pre- and Peri-natal Predictors of Childhood ObesityR37HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2012 to 2015
$4.5M
Maternal fatty acids, child obesity, and asthma immunityR01HL075504 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2004 to 2007
$2.4M
Effects of prenatal diet and mercury exposure on child behavior and developmentR01ES016314 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2008 to 2011
$1.4M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
NHLBI NIH HHS R01 HL075504NICHD NIH HHS K24 HD069408NICHD NIH HHS R01 HD034568NICHD NIH HHS R37 HD034568NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK092924NIEHS NIH HHS R01 ES016314
6 · The paper itself

Abstract

backgroundIn adults, adherence to the Mediterranean diet has been inversely associated with cardiovascular risk, but the extent to which diet in pregnancy is associated with offspring adiposity is unclear. We aimed to investigate the association between adherence to Mediterranean diet in pregnancy and offspring cardiometabolic traits in two pregnancy cohorts.

methodsWe studied 997 mother-child pairs from Project Viva in Massachusetts, USA, and 569 pairs from the Rhea study in Crete, Greece. We estimated adherence to the Mediterranean diet with an a priori defined score (MDS) of nine foods and nutrients (0 to 9). We measured child weight, height, waist circumference, skin-fold thicknesses, blood pressure, and blood levels of lipids, c-reactive protein and adipokines in mid-childhood (median 7.7 years) in Viva, and in early childhood (median 4.2 years) in Rhea. We calculated cohort-specific effects and pooled effects estimates with random-effects models for cohort and child age.

resultsIn Project Viva, the mean (SD, standard deviation) MDS was 2.7 (1.6); in Rhea it was 3.8 (1.7). In the pooled analysis, for each 3-point increment in the MDS, offspring BMI z-score was lower by 0.14 units (95% CI, -0.15 to -0.13), waist circumference by 0.39 cm (95% CI, -0.64 to -0.14), and the sum of skin-fold thicknesses by 0.63 mm (95% CI, -0.98 to -0.28). We also observed lower offspring systolic (-1.03 mmHg; 95% CI, -1.65 to -0.42) and diastolic blood pressure (-0.57 mmHg; 95% CI, -0.98 to -0.16).

conclusionGreater adherence to Mediterranean diet during pregnancy may protect against excess offspring cardiometabolic risk.

Indexed as

Diet, MediterraneanAdiposityAdultAnthropometryBlood PressureCardiovascular DiseasesChildChild, PreschoolC-Reactive ProteinFeeding BehaviorFemaleGreeceHumansLipidsMaleMassachusettsC-Reactive ProteinLipidsBlood pressurecohort studydietlipidsobesitypregnancy

Identifiers

PMID28160450
PMCPMC5697744
OpenAlexW2583518506

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.