ArticlePlant biotechnology journal2017
Spearmint R2R3-MYB transcription factor MsMYB negatively regulates monoterpene production and suppresses the expression of geranyl diphosphate synthase large subunit (MsGPPS.LSU).
Article in Plant biotechnology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 143 citations in OpenAlex.
- Integrated omics identifies VviGTs and VviMYB174 as drivers of glycosylated monoterpenoid accumulation in 'Ruiduhongyu' grapes.Horticulture research · 2026Article
- OfWRKY48 coordinates floral aroma biosynthesis by dual regulation of MEP pathway and carotenoid metabolism inHorticulture research · 2026Article
- The transcription factorHorticulture research · 2026Article
- Squalene inPlants (Basel, Switzerland) · 2026Article
- TPS-mediated transcription reprogramming during the robust aroma formation in Daphne odora flowers.BMC plant biology · 2026Article
- Article
- Divergent volatilomes between wild and cultivated strawberries: MYB transcription factors underlie flavor differences.Food chemistry. Molecular sciences · 2025Article
- Glycyrrhiza, a commonly used medicinal herb: Review of species classification, pharmacology, active ingredient biosynthesis, and synthetic biology.Journal of advanced research · 2025Review
- The PlMYB73-PlMYB70-PlMYB108 complex regulatesHorticulture research · 2025Article
- Biosynthetic Machinery to Abiotic Stress-Driven Emission: Decoding Multilayer Regulation of Volatile Terpenoids in Plants.Antioxidants (Basel, Switzerland) · 2025Review
- Review
- Paclobutrazol induces triterpenoid biosynthesis via downregulation of the negative transcriptional regulator SlMYB in Sanghuangporus lonicericola.Communications biology · 2025Article
- Structure, evolution, and roles of MYB transcription factors proteins in secondary metabolite biosynthetic pathways and abiotic stresses responses in plants: a comprehensive review.Frontiers in plant science · 2025Review
- Article
- Smells like lemons: MYB-ADH gene cluster regulates citral biosynthesis in Litsea cubeba.Plant physiology · 2024Article
- Full-Length Transcriptome Sequencing and RNA-Seq Analysis Offer Insights into Terpenoid Biosynthesis inGenes · 2024Article
- LiNAC100 contributes to linalool biosynthesis by directly regulating LiLiS in Lilium 'Siberia'.Planta · 2024Article
- Identification of MYB gene family in medicinal tea tree Melaleuca alternifolia (Maiden and Betche) cheel and analysis of members regulating terpene biosynthesis.Molecular biology reports · 2024Article
- A non-canonicalFrontiers in plant science · 2024Article
- Terpene produced by coexpression of the TPS and P450 genes from Lavandula angustifolia protects plants from herbivore attacks during budding stages.BMC plant biology · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many aromatic plants, such as spearmint, produce valuable essential oils in specialized structures called peltate glandular trichomes (PGTs). Understanding the regulatory mechanisms behind the production of these important secondary metabolites will help design new approaches to engineer them. Here, we identified a PGT-specific R2R3-MYB gene, MsMYB, from comparative RNA-Seq data of spearmint and functionally characterized it. Analysis of MsMYB-RNAi transgenic lines showed increased levels of monoterpenes, and MsMYB-overexpressing lines exhibited decreased levels of monoterpenes. These results suggest that MsMYB is a novel negative regulator of monoterpene biosynthesis. Ectopic expression of MsMYB, in sweet basil and tobacco, perturbed sesquiterpene- and diterpene-derived metabolite production. In addition, we found that MsMYB binds to cis-elements of MsGPPS.LSU and suppresses its expression. Phylogenetic analysis placed MsMYB in subgroup 7 of R2R3-MYBs whose members govern phenylpropanoid pathway and are regulated by miR858. Analysis of transgenic lines showed that MsMYB is more specific to terpene biosynthesis as it did not affect metabolites derived from phenylpropanoid pathway. Further, our results indicate that MsMYB is probably not regulated by miR858, like other members of subgroup 7.
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Registered trials
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