Evidence map›Paper›PMID 28160223›Full record

ArticleJournal of autism and developmental disorders2017

Quantitative Sensory Testing in adults with Autism Spectrum Disorders.

Odette Fründt, Wiebke Grashorn, Daniel Schöttle, Ina Peiker, Nicole David, Andreas K Engel, Katarina Forkmann, Nathalie Wrobel, Alexander Münchau, Ulrike Bingel

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06659731 (Pain Perception in Autism. Study Through Quantitative Sensory Testing and Psychophysiological Correlates), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06659731 recruitingnot on this mapstarted 2024, after this paper: background citation

Pain Perception in Autism. Study Through Quantitative Sensory Testing and Psychophysiological Correlates

TypeobservationalSponsorIRCCS Eugenio MedeaRan2024 to 2025Enrolled50ConditionsAutism Spectrum Disorder (ASD), Pain PerceptionArmsQuantitative Sensory testing (QST), EEG
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Pain experience and perception in individuals with Snijders Blok-Campeau syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Pain assessment in autism: updating the ethical and methodological challenges through a state-of-the-art review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
  11. Atypical Tactile Perception in Early Childhood Autism.Journal of autism and developmental disorders · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Observational
  17. Modulation of the thermosensory system by oxytocin.Frontiers in molecular neuroscience · 2022
    Review
  18. Article
  19. Pain Modulation Mechanisms in ASD Adults.Journal of autism and developmental disorders · 2020
    Article
  20. A Quantitative Sensory Testing Approach to Pain in Autism Spectrum Disorders.Journal of autism and developmental disorders · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Odette FründtDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. o.fruendt@uke.de.
Wiebke GrashornDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Daniel SchöttleDepartment of Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ina PeikerDepartment of Psychiatry, University Medical Center Heidelberg, Heidelberg, Germany.
Nicole DavidDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Andreas K EngelDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Katarina ForkmannDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nathalie WrobelDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Alexander MünchauDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ulrike BingelDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Universität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DEHeidelberg University · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Altered sensory perception has been found in patients with autism spectrum disorders (ASD) and might be related to aberrant sensory perception thresholds. We used the well-established, standardized Quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain to investigate 13 somatosensory parameters including thermal and tactile detection and pain thresholds in 13 ASD adults and 13 matched healthy controls with normal IQ values. There were no group differences between somatosensory detection and pain thresholds. Two ASD patients showed paradoxical heat sensations and another two ASD subjects presented dynamic mechanical allodynia; somatosensory features that were absent in controls. These findings suggest that central mechanisms during complex stimulus integration rather than peripheral dysfunctions probably determine somatosensory alterations in ASD.

Indexed as

AdultAutism Spectrum DisorderCase-Control StudiesFemaleHumansMalePain ThresholdSensory ThresholdsYoung AdultAutismHypersensitivityHyposensitivityQuantitative sensory testingSensory thresholds

Identifiers

PMID28160223
OpenAlexW2584125285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.