SynthesisOncotarget2017
The impact of BMI on sperm parameters and the metabolite changes of seminal plasma concomitantly.
Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- BMI is associated with sperm quality and sex hormones in men: a meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Association between body mass index and semen quality: a systematic review and meta-analysis.International journal of obesity (2005) · 2024Pooled it
- Paternal Folate Status and Sperm Quality, Pregnancy Outcomes, and Epigenetics: A Systematic Review and Meta-Analysis.Molecular nutrition & food research · 2020Pooled it
- Body fat percentage in relation to semen characteristics, testicular volume, and reproductive hormones: a cross-sectional study.Human reproduction (Oxford, England) · 2026Article
- Exploring the knowledge, attitudes, and perceptions of young men towards fertility in the UK: A cross-sectional survey.PloS one · 2026Article
- Density gradient centrifugation specifically improves sperm motility in hyperuricemia: evidence from intrauterine insemination cycles - retrospective cohort study.Basic and clinical andrology · 2025Article
- A 10-year longitudinal analysis of the impact of demographic, lifestyle, and medical factors on semen qualities in men in a city in the midwestern region of the United States of America.Asian journal of andrology · 2025Article
- Is a Large Neck Circumference a Predictive Factor for Poor Semen Quality in the Turkish Population?Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects.Nature reviews. Urology · 2025Review
- Do Lifestyle Interventions Mitigate the Oxidative Damage and Inflammation Induced by Obesity in the Testis?Antioxidants (Basel, Switzerland) · 2025Review
- Beyond body mass index: the role of fat distribution in male sperm quality.Frontiers in endocrinology · 2025Article
- Male Fertility as a Proxy for Health.Journal of clinical medicine · 2024Review
- Molecular insights into Sertoli cell function: how do metabolic disorders in childhood and adolescence affect spermatogonial fate?Nature communications · 2024Review
- Interplay between male gonadal function and overall male health.Journal of basic and clinical physiology and pharmacology · 2024Review
- Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review.Journal of personalized medicine · 2024Review
- Phase angle at bioelectric impedance analysis is associated with detrimental sperm quality in idiopathic male infertility: a preliminary clinical study.Frontiers in endocrinology · 2024Article
- Impact of GLP-1 Agonists on Male Reproductive Health-A Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- Articles in the field of infertility (2013-2022): a bibliometric analysis.Journal of assisted reproduction and genetics · 2023Article
- Obesity is associated with quality of sperm parameters in men with infertility: a cross-sectional study.Reproductive health · 2023Article
- Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course.Nature reviews. Cardiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of male infertility increased rapidly worldwide, which coinciding with the epidemic of obesity. However, the impact of weight abnormalities on sperm quality is still contestable. To assess the correlation between BMI and sperm parameters, we searched relevant articles in PubMed, Embase, Web of science, and Wanfang database published until June 2015 without language restriction. Otherwise, we also recruited some participants who attended fertility clinic as well as some general populations in this report. We performed a systematic review and meta-analysis about BMI and sperm parameters containing total sperm count, concentration, semen volume and sperm motility (overall and progressive). Metabolomic analysis of seminal plasma was performed to explore the mechanism from a new perspective. This study found standardized weighted mean differences (SMD) in sperm parameters (total sperm count, sperm concentration, and semen volume) of abnormal weight groups decreased to different degree compared to normal weight. Dose-response analysis found SMD of sperm count, sperm concentration and semen volume respectively fell 2.4%, 1.3% and 2.0% compared with normal weight for every 5-unit increase in BMI. Metabolomic analysis of seminal plasma showed that spermidine and spermine were likely to play a vital role in the spermatogenesis progress. This systematic review with meta-analysis has confirmed there was a relationship between BMI and sperm quality, suggesting obesity may be a detrimental factor of male infertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.