ArticleProceedings of the National Academy of Sciences of the United States of America2017
Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 89 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed, 122 citations in OpenAlex.
- C-X-C chemokine receptor type 5World journal of gastroenterology · 2025Trial
- Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals.Science translational medicine · 2018Trial
- CD8+ T cells with high TGF‑β1 expression cause lymph node fibrosis following HIV infection.Molecular medicine reports · 2018Trial
- High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults.Frontiers in immunology · 2018Trial
- Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7.Cell reports · 2026Article
- Follicular CD8+ T cells in Trypanosoma cruzi infection: helpers or killers depending on the target B cell population.PLoS pathogens · 2025Article
- Review
- Highly immunogenic DNA/LION nanocarrier vaccine potently activates lymph nodes inducing long-lasting immunity in macaques.iScience · 2025Article
- Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells.JCI insight · 2025Article
- Role of follicular homing natural killer cells in HIV infection.Current opinion in HIV and AIDS · 2025Review
- Viral Infection and Dissemination Through the Lymphatic System.Microorganisms · 2025Review
- Multi-omics analysis of SIV-specific CD8+ T cells in multiple anatomical sites.PLoS pathogens · 2024Article
- An angel or a devil? Current view on the role of CD8Journal of translational medicine · 2024Review
- Cytolytic CD8Science immunology · 2023Article
- Follicular CD8+ T Cells Are Elevated in HIV Infection and Induce PD-L1 on B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- CD8 T-cell heterogeneity during T-cell exhaustion and PD-1-targeted immunotherapy.International immunology · 2022Review
- TGF-β promotes stem-like T cells via enforcing their lymphoid tissue retention.The Journal of experimental medicine · 2022Article
- Aging induces severe SIV infection accompanied by an increase in follicular CD8+ T cells with overactive STAT3 signaling.Cellular & molecular immunology · 2022Article
- Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques.Nature communications · 2022Article
- Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedCorrection for Mylvaganam et al., Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection.2017 · Mavinger, Maud [corrected to Mavigner, Maud]
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
A significant challenge to HIV eradication is the elimination of viral reservoirs in germinal center (GC) T follicular helper (Tfh) cells. However, GCs are considered to be immune privileged for antiviral CD8 T cells. Here, we show a population of simian immunodeficiency virus (SIV)-specific CD8 T cells express CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor required for homing to GCs) and expand in lymph nodes (LNs) following pathogenic SIV infection in a cohort of vaccinated macaques. This expansion was greater in animals that exhibited superior control of SIV. The CXCR5+ SIV-specific CD8 T cells demonstrated enhanced polyfunctionality, restricted expansion of antigen-pulsed Tfh cells in vitro
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.