Evidence map›Paper›PMID 28159890›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Multiple functional self-association interfaces in plant TIR domains.

Xiaoxiao Zhang, Maud Bernoux, Adam R Bentham, Toby E Newman, Thomas Ve, Lachlan W Casey, Tom M Raaymakers, Jian Hu, Tristan I Croll, Karl J Schreiber and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
32.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 141 citations in OpenAlex.

  1. Article
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  4. Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026
    Review
  5. TheProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  8. Article
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  14. Review
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  16. Article
  17. Article
  18. NLRscape: an atlas of plant NLR proteins.Nucleic acids research · 2023
    Article
  19. Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 6 countries.

Xiaoxiao ZhangSchool of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre and Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
Maud BernouxAgriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia; stask@berkeley.edu maud.bernoux@csiro.au simon.williams@anu.edu.au peter.dodds@csiro.au b.kobe@uq.edu.au.
Adam R BenthamSchool of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre and Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
Toby E NewmanDepartment of Life Sciences, and School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea.
Thomas VeSchool of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre and Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
Lachlan W CaseySchool of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre and Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
Tom M RaaymakersAgriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.ORCID 0000-0003-1056-7177
Jian HuAgriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.
Tristan I CrollSchool of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD 4001, Australia.
Karl J SchreiberDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.
Brian J StaskawiczDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720; stask@berkeley.edu maud.bernoux@csiro.au simon.williams@anu.edu.au peter.dodds@csiro.au b.kobe@uq.edu.au.
Peter A AndersonSchool of Biological Sciences, Faculty of Science and Engineering, Flinders University, Adelaide, SA 5001, Australia.
Kee Hoon SohnDepartment of Life Sciences, and School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea.
Simon J WilliamsSchool of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre and Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia; stask@berkeley.edu maud.bernoux@csiro.au simon.williams@anu.edu.au peter.dodds@csiro.au b.kobe@uq.edu.au.
Peter N DoddsAgriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia; stask@berkeley.edu maud.bernoux@csiro.au simon.williams@anu.edu.au peter.dodds@csiro.au b.kobe@uq.edu.au.
Bostjan KobeSchool of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre and Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia; stask@berkeley.edu maud.bernoux@csiro.au simon.williams@anu.edu.au peter.dodds@csiro.au b.kobe@uq.edu.au.ORCID 0000-0001-9413-9166
Commonwealth Scientific and Industrial Research Organisation · AUThe University of Queensland · AUPohang University of Science and Technology · KRUniversity of California, Berkeley · USAustralian National University · AUFlinders University · AUGriffith University · AUQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The self-association of Toll/interleukin-1 receptor/resistance protein (TIR) domains has been implicated in signaling in plant and animal immunity receptors. Structure-based studies identified different TIR-domain dimerization interfaces required for signaling of the plant nucleotide-binding oligomerization domain-like receptors (NLRs) L6 from flax and disease resistance protein RPS4 from

Indexed as

Gene Expression Regulation, PlantAmino Acid SequenceArabidopsisArabidopsis ProteinsBinding SitesCell DeathFlaxHost-Pathogen InteractionsModels, MolecularMutationNicotianaPeronosporaPlant DiseasesPlant ImmunityPlant ProteinsProtein BindingArabidopsis ProteinsL6 protein, Linum usitatissimumNPR1 protein, ArabidopsisPlant ProteinsRecombinant Proteinsrps4 protein, plantSNC1 protein, ArabidopsisNLRplant disease resistanceplant immunitysignaling by cooperative assembly formationTIR domain

Identifiers

PMID28159890
PMCPMC5347627
OpenAlexW2584708022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.