Evidence map›Paper›PMID 28159867›Full record

ArticleJournal of lipid research2017

Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine

Jelske N van der Veen, Susanne Lingrell, Xia Gao, Abhijit Takawale, Zamaneh Kassiri, Dennis E Vance, René L Jacobs

Open access · hybridFull text read
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. PPARα regulates ER-lipid droplet protein Calsyntenin-3β to promote ketogenesis in hepatocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Targeting fatty acid metabolism for fibrotic disorders.Archives of pharmacal research · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jelske N van der VeenGroup on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Susanne LingrellGroup on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Xia GaoGroup on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Abhijit TakawaleDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Zamaneh KassiriDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Dennis E VanceGroup on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
René L JacobsGroup on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada; Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada. Electronic address: rjacobs@ualberta.ca.
University of Alberta · CA

Funding

CIHR MOP-5182
6 · The paper itself

Abstract

Mice lacking phosphatidylethanolamine

Indexed as

AnimalsDisease Models, AnimalEndoplasmic Reticulum StressEzetimibeFenofibrateHumansInsulin ResistanceLipid MetabolismLipoproteins, VLDLLiverMiceMice, KnockoutNon-alcoholic Fatty Liver DiseaseObesityOxidation-ReductionPhosphatidylethanolamine N-MethyltransferaseEzetimibeFenofibrateLipoproteins, VLDLPEMT protein, mousePhosphatidylethanolamine N-MethyltransferaseTriglyceridesvery low density lipoprotein triglyceridefibric acidsliver fibrosisnonalcoholic fatty liver diseaseperoxisome proliferator-activated receptor-αphosphatidylcholinesteatohepatitis

Identifiers

PMID28159867
PMCPMC5392742
OpenAlexW2585333732

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.