ArticleAmerican journal of physiology. Heart and circulatory physiology2017
Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons.
Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- The orexin system as a pharmacological target in inflammation: peripheral mechanisms and safety implications.Frontiers in pharmacology · 2026Review
- Molecular and cellular neurocardiology in heart disease.The Journal of physiology · 2025Review
- Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain: A Comprehensive Guide.Neuroscience bulletin · 2024Review
- Activation of oxytocinergic neurons enhances torpor in mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Orexin, Sleep, Sympathetic Neural Activity, and Cardiovascular Function.Hypertension (Dallas, Tex. : 1979) · 2022Review
- Adolescent alcohol exposure increases orexin-A/hypocretin-1 in the anterior hypothalamus.Alcohol (Fayetteville, N.Y.) · 2020Article
- Metabolic Effects of Light at Night are Time- and Wavelength-Dependent in Rats.Obesity (Silver Spring, Md.) · 2020Article
- Cell type- and pathway-specific synaptic regulation of orexin neurocircuitry.Brain research · 2020Review
- MRI-guided robotic arm drives optogenetic fMRI with concurrent CaNature communications · 2019Article
- The link between narcolepsy and autonomic cardiovascular dysfunction: a translational perspective.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Statistical considerations in reporting cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2018Article
- Local Corticotropin-Releasing Factor Signaling in the Hypothalamic Paraventricular Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Regulation of Lateral Hypothalamic Orexin Activity by Local GABAergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Sympathetic nerve activity and neuro-inflammation: Who is in the driver's seat?Acta physiologica (Oxford, England) · 2018Article
- Combined hypoxia and hypercapnia, but not hypoxia alone, suppresses neurotransmission from orexin to hypothalamic paraventricular spinally-projecting neurons in weanling rats.Brain research · 2018Article
- Functional Organization of the Sympathetic Pathways Controlling the Pupil: Light-Inhibited and Light-Stimulated Pathways.Frontiers in neurology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Orexin neurons, and activation of orexin receptors, are generally thought to be sympathoexcitatory; however, the functional connectivity between orexin neurons and a likely sympathetic target, the hypothalamic spinally projecting neurons (SPNs) in the paraventricular nucleus of the hypothalamus (PVN) has not been established. To test the hypothesis that orexin neurons project directly to SPNs in the PVN, channelrhodopsin-2 (ChR2) was selectively expressed in orexin neurons to enable photoactivation of ChR2-expressing fibers while examining evoked postsynaptic currents in SPNs in rat hypothalamic slices. Selective photoactivation of orexin fibers elicited short-latency postsynaptic currents in all SPNs tested (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.