ArticleThe Journal of experimental medicine2017
Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.
Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Fatty Acid Metabolism Rewires Glioblastoma Progression and Treg-Mediated Immune Resistance.Cancers · 2026Review
- HIV Nef disrupts Lck signaling by inducing aberrant phosphorylation of its substrates.ImmunoHorizons · 2025Article
- Current trends in sensitizing immune checkpoint inhibitors for cancer treatment.Molecular cancer · 2024Review
- The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells.PloS one · 2024Article
- A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation.Biology · 2023Review
- Combined immunodeficiency caused by pathogenic variants in theFrontiers in immunology · 2023Article
- Article
- ZAP70, too little, too much can lead to autoimmunity.Immunological reviews · 2022Review
- Effects of PD-1 Signaling on Immunometabolic Reprogramming.Immunometabolism · 2022Article
- Negative Regulation of Zap70 by Lck Forms the Mechanistic Basis of Differential Expression in CD4 and CD8 T Cells.Frontiers in immunology · 2022Article
- Article
- Cbl-b deficiency prevents functional but not phenotypic T cell anergy.The Journal of experimental medicine · 2021Article
- An Unusual MHC Molecule Generates Protective CD8+ T Cell Responses to Chronic Infection.Frontiers in immunology · 2020Article
- Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes.Journal for immunotherapy of cancer · 2019Article
- ZAP-70 in Signaling, Biology, and Disease.Annual review of immunology · 2018Review
- Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms.Frontiers in immunology · 2017Article
- T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology. Here, we analyze mice with a hypermorphic Zap70 mutation, W131A, which destabilizes the autoinhibitory conformation of Zap70, rendering the kinase in a semiactive state. W131A mutant mice with wild-type T cell receptor (TCR) repertoires exhibited relatively normal T cell development. However, crossing the W131A mutant mice to OTII TCR transgenic mice resulted in increased negative selection of OTII
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