Evidence map›Paper›PMID 28159786›Full record

ArticleApplied and environmental microbiology2017

Evolution of Pectobacterium Bacteriophage ΦM1 To Escape Two Bifunctional Type III Toxin-Antitoxin and Abortive Infection Systems through Mutations in a Single Viral Gene.

Tim R Blower, Ray Chai, Rita Przybilski, Shahzad Chindhy, Xinzhe Fang, Samuel E Kidman, Hui Tan, Ben F Luisi, Peter C Fineran, George P C Salmond

Open access · hybridAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The great phage escape: Activating and escaping lactococcal antiphage systems.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Ejectosome ofPNAS nexus · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Different genetic and morphological outcomes for phages targeted by single or multiple CRISPR-Cas spacers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
  18. Article
  19. Viruses · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Tim R BlowerDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Ray ChaiDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Rita PrzybilskiDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Shahzad ChindhyDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Xinzhe FangDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Samuel E KidmanDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Hui TanDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Ben F LuisiDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Peter C FineranDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-4639-6704
George P C SalmondDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom gpcs2@cam.ac.uk.
University of Cambridge · GBUniversity of Otago · NZ

Funding

Biotechnology and Biological Sciences Research Council BB/H002677/1Wellcome Trust
6 · The paper itself

Abstract

Some bacteria, when infected by their viral parasites (bacteriophages), undergo a suicidal response that also terminates productive viral replication (abortive infection [Abi]). This response can be viewed as an altruistic act protecting the uninfected bacterial clonal population. Abortive infection can occur through the action of type III protein-RNA toxin-antitoxin (TA) systems, such as ToxIN

Indexed as

Evolution, MolecularGenes, ViralAntitoxinsBacterial ToxinsBacteriophagesGenome, ViralHost-Pathogen InteractionsMutationPectobacteriumSequence Analysis, DNAAntitoxinsBacterial Toxinsabortive infectionbacteriophage-bacterium interactionPectobacterium atrosepticumtype III toxin-antitoxinΦM1

Identifiers

PMID28159786
PMCPMC5377504
OpenAlexW2583715291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.